Project Grant R00HD115786
- Federal Project Grant Award Summary Arizona State University received a $2.97 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded September 15, 2025, for a four-year project period through September 14, 2029. The award funds research on "Developmental Programming of Adult Stem Cells," which investigates how early-life maternal...
- Federal Grant Award Summary The University of Arizona received a $1,276,640 Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), awarded on September 17, 2025, with completion targeted for September 16, 2028. This award funds fundamental research investigating the concept of nutritional memory—the hypothesis that early-life dietary experiences create lasting molecular impressions on gut neuropod cells that...
- Federal Grant Award Summary The University of Arizona received a $1,207,970 Project Grant award dated August 12, 2025, from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865) to advance understanding of motile cilia function in human fallopian tubes and develop innovative endoscopic imaging technologies for clinical investigation of cilia dysfunction. The research addresses a critical gap in female...
- Federal Grant Award Summary The University of California, San Francisco received a $2.78 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded on September 15, 2025, with completion targeted for September 14, 2029. The award funds research to advance understanding of Hirschsprung disease (HSCR), a severe congenital gastrointestinal anomaly...
- Federal Project Grant Award Summary The University of North Carolina at Chapel Hill received a $113,089 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate enteroendocrine cell (EEC) regulation of intestinal barrier function. The award, dated February 15, 2026, with completion targeted for January 31, 2028, supports research utilizing...
- Grant Award Summary The Washington University, through its Office of Sponsored Research Services, received a $999,056 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award, effective September 1, 2025, through August 31, 2027, supports research investigating the role of the early-life gut microbiome on immunoglobulin A (IgA) and colonic immune development. The...
- Federal Grant Award Summary The National Institute of Child Health and Human Development awarded the University of Virginia a $1.43 million Project Grant (CFDA 93.865: Child Health and Human Development Extramural Research) on September 17, 2025, to conduct a Phase II clinical trial addressing childhood stunting in Bangladesh through treatment of small intestine bacterial overgrowth (SIBO). The project will deliver two primary research objectives: (1) a Phase IIA treatment optimization trial...
- Federal Grant Award Summary The University of Chicago received a $770,995 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective February 2, 2026, with a completion date of November 30, 2029. This award supports investigator-initiated basic biomedical research aimed at elucidating the mechanisms of intestinal mucosal healing following inflammatory...
- Federal Grant Award Summary Baylor College of Medicine received a $425,015 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) with an award date of August 1, 2025, and completion date of July 31, 2027. The research project investigates interindividual epigenetic variation at birth and its association with subsequent risk of dysbiosis and necrotizing enterocolitis (NEC) in...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of Pennsylvania a $798,039 Project Grant effective March 1, 2026, through January 31, 2030, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This research initiative will deliver computational modeling and experimental research aimed at understanding self-organization mechanisms in the intestinal epithelium, specifically...
Grant Award Summary The University of Arizona received a $249,000 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded on May 1, 2026, with a completion date of April 30, 2029. This research initiative focuses on characterizing the transcriptional regulation and function of BEST4+ cells, a newly discovered intestinal cell type that is depleted in inflammatory bowel disease patients. The project aims to resolve whether BEST4+ cell loss causes disease or results from disease progression, and to understand how dysfunction of these cells contributes to intestinal pathology. The deliverables include comprehensive experimental analysis using zebrafish models to elucidate BEST4+ cell development and physiological function through cell ablation studies, single-cell RNA sequencing analysis, and assessment of disease hallmarks including pH changes, epithelial barrier integrity, and inflammatory responses. The project will also identify and perturb genes predicted to regulate BEST4+ cell function and characterize the intestinal cell response to inflammation in the presence and absence of BEST4+ cells. These research activities are expected to advance understanding of intestinal homeostasis and provide foundational knowledge applicable to inflammatory bowel disease pathogenesis and potential therapeutic interventions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 5/7/26 |