Project Grant R01HD119025
- Federal Grant Award Summary Duke University's Office of Research Administration received a $114,458 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) effective August 1, 2025, with completion scheduled for July 31, 2027. This award funds research addressing the fundamental biological mechanisms underlying size memory during zebrafish appendage regeneration, with...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $1,123,280 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective August 1, 2025, with a completion date of April 30, 2030. The research will be conducted in Durham, North Carolina, and focuses on elucidating the signaling and cellular mechanisms underlying notochord...
- Federal Grant Award Summary Duke University received a $612,587 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded on March 18, 2026, with a completion date of January 31, 2031. The award funds research conducted in Durham, North Carolina to identify the mechanisms through which the microbiome regulates postnatal growth and lipid metabolism in...
- Federal Project Grant Award Summary Duke University received a $581,258 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective June 1, 2026 through February 28, 2031. The award funds research investigating transposable elements (TEs) as mechano-response enhancer elements that regulate human embryonic stem cell (hESC) fate in response to mechanical stimuli. The...
- Federal Project Grant Award Summary Duke University received a $225,324 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective September 1, 2025, through August 31, 2028. The research project, titled "Understanding the Role of Mitochondrial Specialization in Early Development," delivers fundamental scientific research investigating how mitochondrial...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $694,448 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective July 1, 2026, through March 31, 2031. This award supports fundamental research investigating the multinucleated syncytiotrophoblast (STB), a specialized placental tissue that serves as the critical...
- Federal Project Grant Award Summary Duke University received a $1.76 million Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective September 1, 2025, through August 31, 2029. The award funds research investigating the effects of parents' participation in public work programs (PWPs) on children's health and education outcomes in select low- and middle-income...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $1.38 million Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded September 4, 2025, with completion targeted for July 31, 2030. The project, titled "Improving Institutional Processes to Reduce Patient Harm Using Evidence-Based Standards," addresses critical gaps...
- Federal Project Grant Award Summary Duke University's Office of Research Administration is conducting a two-year research initiative funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The project, titled "Investigating Nuclear Plasticity in the Human Placental Syncytium," is awarded $121,515 and will be performed in Durham, North Carolina, with an award date of August...
- Federal Project Grant Summary Duke University's Office of Research Administration is executing a research infrastructure project funded by the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351). This $444,125 award, which commenced July 1, 2026 and concludes June 30, 2028, supports the development of zebrafish tools for investigating enteroendocrine hormone biology. The project focuses on characterizing the structure and function...
Duke University received a $686,184 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective July 1, 2026, through June 30, 2031. The award funds research into the transcriptional and environmental regulation of lysosome-rich enterocytes (LREs), specialized absorptive cells in the neonatal ileum that facilitate unique dietary protein uptake and intracellular digestion. Impaired LRE function has been associated with neonatal growth faltering and protein malnutrition, yet fundamental knowledge gaps exist regarding the mechanisms governing LRE formation and function. The research leverages zebrafish as a model organism to develop in vivo assays and molecular markers for studying LREs in live animals. Duke's research team will employ single-cell RNA sequencing to characterize the transcriptional profiles of LREs and the ileal region, identify transcription factors that define LRE identity, and elucidate how LRE activity is modulated by nutritional and microbial cues, including lipids from circulating lipoproteins and gut microbiota. The project objectives are to define the transcriptional pathways that specify LRE identity in the ileum and to determine how external stimuli regulate LRE activity, with findings expected to advance understanding of neonatal intestinal physiology and potential interventions for protein malnutrition.Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $686.2k | 6/23/26 |