Project Grant R01EY037534
- Federal Project Grant Award Summary The Medical College of Wisconsin, Inc. received a $856,698 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded on July 1, 2025, with a project completion date of March 31, 2030. This award supports mechanistic research into retinal ganglion cell (RGC) genesis, addressing a critical gap in understanding the developmental factors necessary for generating these specialized neurons that serve as the sole...
- Federal Grant Award Summary Baylor College of Medicine received a $646,167 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective April 1, 2026 through March 31, 2031. The award funds investigations into the cellular and molecular mechanisms underlying Age-Related Macular Degeneration (AMD), the leading cause of vision loss in elderly populations. The research applies high-throughput functional genomics approaches to identify causal...
- Federal Grant Award Summary The University of Wisconsin–Madison received a $249,672 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), with an award date of May 8, 2026 and completion deadline of November 30, 2027. This grant supports research investigating light adaptation mechanisms in regionally and functionally distinct primate retinal circuits. The primary research deliverables include empirical findings on how the fovea and peripheral...
- Federal Project Grant Award Summary The University of Wisconsin–Madison received a $249,000 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 15, 2025, with a completion date of July 31, 2028. This award supports fundamental neuroscience research investigating the principles of operation governing neural learning circuits, with a specific focus on motor adaptation in the cerebellum. The research leverages the highly...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant of $423,866 under the Vision Research program (CFDA 93.867) to develop mini-USH2A gene therapy for treating Usher Syndrome Type 2A (USH2A), the most common inherited condition causing combined hearing and vision loss. The research project, which commenced May 1, 2026 and concludes April 30, 2028, focuses on creating a functional minigene construct that addresses the...
- Federal Grant Award Summary The National Eye Institute (NEI), administering funds under the Vision Research program (CFDA 93.867), awarded the University of Maryland, Baltimore a $249,000 Project Grant effective September 30, 2025, with completion targeted for August 31, 2028. This research project will develop and validate novel fluorescence lifetime imaging technologies to assess the retinal pigment epithelium (RPE) cell mosaic in the living human eye by characterizing intracellular pigment...
- Federal Grant Award Summary The University of Wisconsin–Madison received a $269,040 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded August 1, 2025, with completion targeted for July 14, 2027. This research project delivers scientific investigation into retinal biomarkers of prodromal Parkinson disease, aiming to identify novel diagnostic indicators that appear years before motor symptoms manifest. The research employs a two-phase...
- Federal Grant Award Summary Baylor College of Medicine received a $1.6 million project grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded September 30, 2025, with completion scheduled for September 29, 2028. The research investigates the molecular mechanisms governing Muller glial cell (MGC) reprogramming and proliferation through modulation of the Hippo and Wnt signaling pathways. The project aims to identify cellular and molecular strategies to...
- Federal Project Grant Award Summary The National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) awarded $902,000 to the University of California, San Francisco for a two-year project (September 1, 2025 – August 31, 2027) to conduct multimodal characterization of a novel inherited mouse model of glaucoma. The primary deliverables include comprehensive phenotypic characterization of GLIS1 knockout mice across two genetic backgrounds, evaluating structural and functional...
- Federal Grant Award Summary The University of Washington received a $458,288 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective May 1, 2026 through February 28, 2030. This five-year research initiative will advance regenerative therapies for retinal neuron loss by investigating methods to stimulate Müller glia cells to regenerate damaged retinal neurons in humans and non-human primates. The project will deliver research products...
The Medical College of Wisconsin, Inc. received a $590,839 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective April 15, 2026 through March 31, 2030. This multiple-principal investigator application addresses the cellular mechanisms of MYO7A in the retina, specifically investigating how mutations in this gene cause Usher Syndrome 1B (USH1B), a condition characterized by congenital deafness, vestibular deficiencies, and progressive photoreceptor degeneration leading to vision loss. The research deliverables include fundamental scientific findings regarding MYO7A cellular functions and its splice variants within the retina, generated through complementary experimental models including patient-derived retinal pigment epithelium (RPE) cells, MYO7A-mutant mice and pigs, and MYO7AB zebrafish mutants. The project specifically investigates mechanisms underlying cell junction dysfunction, evaluates the role of MYO7A isoforms, and determines whether specific MYTH4-FERM domain variants can prevent USH1B pathologies including photoreceptor loss when re-expressed in relevant retinal cell types. The anticipated products are empirical research findings that advance understanding of both cell-autonomous and non-cell-autonomous roles of MYO7A in photoreceptor health, with potential implications for therapeutic development addressing vision loss in Usher Syndrome patients.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $590.8k | 4/7/26 |