Project Grant R01DA065668
- Federal Grant Award Summary The University of Michigan received a $170,744 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective June 17, 2025, with a completion date of December 31, 2025. This research initiative investigates the glucocorticoid receptor (GR) as a neuromolecular mechanism underlying inhibitory control deficits associated with substance use disorder (SUD). The project examines how the GR...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the Regents of the University of Michigan $172,144 through the Drug Use and Addiction Research Programs (CFDA 93.279) to support research on optimizing chemical- and light-dependent protein switches for controlling opioid peptide activity with temporal control. The grant, awarded on June 26, 2025, funds research designed to advance understanding of mu opioid receptor (MOR) mechanisms and their role in pain...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the Regents of the University of Michigan $325,904 on March 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop machine learning methods for real-time modeling and perturbation of stimulus-shaped neural manifolds. The project, which extends through December 31, 2028, will produce generalizable computational tools designed to construct low-dimensional neural manifolds shaped by...
- Federal Grant Award Summary The University of Michigan received a $595,171 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded May 1, 2026, with completion targeted for February 28, 2031. This research project investigates the functional anatomy, physiology, and behavioral responses mediated by mu opioid receptor (MOR) signaling on medial thalamic neurons. The research addresses a critical gap in understanding...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded the Regents of the University of Minnesota a $423,500 Project Grant effective April 1, 2026, through March 31, 2028. This award supports research investigating the therapeutic potential of M5 receptor targeting to mitigate stress-induced increases in drug reward vulnerability. The project examines how chronic stress disrupts muscarinic M5 receptor...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $1.54M under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Research Foundation for the State University of New York to support a five-year research project running from August 1, 2025, through April 30, 2030. The project investigates the interplay between limbic norepinephrine and dopamine circuits in sex differences in reward and aversion. The research addresses a critical gap in understanding...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Alabama at Birmingham a $173,692 Project Grant on June 19, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct molecular and functional characterization of transcriptionally defined subpopulations of ventral tegmental area (VTA) dopamine neurons. The project, which extends through October 31, 2027, addresses the critical public health challenge of substance use disorder...
- Federal Project Grant Award Summary New York University has been awarded $201,250 by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) for a two-year project period from June 1, 2025, through May 31, 2027. This Project Grant supports basic neuroscience research investigating the synaptic organization of cholinergic interneurons in the nucleus accumbens, a brain region critical to motivated behaviors and implicated in substance use...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $613,786 to The Regents of the University of California, San Francisco under the Drug Use and Addiction Research Programs (CFDA 93.279) Project Grant, effective September 1, 2025, through May 31, 2030. This research initiative investigates a newly discovered aspect of dopamine signaling, specifically examining how D1 dopamine receptors signal from both the plasma membrane and the Golgi apparatus in medium spiny...
- Federal Project Grant Summary: Ventral Tegmental Area Neuromedin S Expression and Signaling in Opioid Responses Michigan State University received a $495,345 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded June 1, 2026, with completion targeted for March 31, 2031. The research investigates the neurobiological mechanisms underlying opioid addiction by examining neuromedin S (NMS) expression and signaling in...
The National Institute on Drug Abuse awarded a Project Grant of $386,301.00 to the Regents of the University of Michigan under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning May 1, 2026 and concluding February 28, 2031. This award supports basic neuroscience research investigating axonal mechanisms that regulate dopamine release in the striatum, with particular focus on understanding how striatal cholinergic interneurons modulate dopaminergic axon excitability. The research employs direct axonal voltage recording techniques to elucidate the complexities of cholinergic-dopaminergic synaptic transmission and improve understanding of nicotine use disorder etiology. The research deliverables include scientific findings on the physiological mechanisms controlling dopamine release through axo-axonic excitatory synaptic transmission in the striatum. By clarifying how striatal cholinergic interneurons regulate dopaminergic axon excitability, this work addresses a fundamental gap in understanding substance use disorder pathology and contributes to the Drug Use and Addiction Research Programs' objective of developing new knowledge and approaches for prevention, diagnosis, and treatment of drug use and addiction.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $386.3k | 4/29/26 |