Project Grant R01DA061880
- This federal Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $226,608.00 to support research on dissecting the mechanisms of dopamine transmission and its roles in reward-related behaviors. The research will investigate how dopamine signaling occurs at the subcellular level and the implications for neuropsychiatric diseases and substance abuse disorders. The grant was awarded to the University of Colorado-Denver on...
- This federal Project Grant award of $811,112 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research on the network and circuit dynamics underlying dopaminergic control of sudden insight learning. The principal investigator and research team at the University of California, San Francisco (UCSF) will use a combination of large-scale two-photon calcium imaging, high-density electrophysiology, dopamine sensor fiber...
- This $480,000 Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop new tools to facilitate the study of how drugs of abuse interact with G protein-coupled receptors (GPCRs) and alter their signaling. The key products and services to be delivered under this 5-year grant include: Generation of chemical biology tools to enable time-resolved cryogenic electron microscopy imaging of GPCR...
- This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop methods for integrating large-scale electron microscopy (EM) brain imaging data with functional and behavioral recordings. The $1,100,864 project, spanning from September 30, 2024 to September 29, 2027, will focus on relating the structure and function of neural circuits in the Drosophila brain. The proposed research seeks to...
- This federal Project Grant award of $180,606.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund research at the Icahn School of Medicine at Mount Sinai to investigate the interplay between drug-induced long-term synaptic proteomic adaptations and the underlying transcriptional responses that drive these adaptations in a cell-type and circuit-specific manner within the brain's reward regions. The research aims to...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, supports research under the Drug Use and Addiction Research Programs (CFDA 93.279) on the interplay between norepinephrine and dopamine circuits in the brain and their role in sex differences in reward and aversion. The $781,032 award, spanning August 2025 to April 2030, will map the anatomical and neurochemical distribution of norepinephrine projections from the locus...
- This federal Project Grant award of $629,844 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant funds research at Duke University to elucidate the function of the ventral tegmental area (VTA) neural circuits and their role in learning and performing motivated behaviors. The research will utilize bidirectional optogenetics, in vivo electrophysiology and photometry, and quantitative behavioral measurements to...
- This $436,050 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate cell type and circuit-specific epigenetic mechanisms underlying cocaine addiction. The research will utilize a mouse model of repeated cocaine exposure to study how cocaine-induced molecular changes in specific brain regions and neuronal circuits lead to the development of addictive behaviors. The goal is to...
- This $129,132 project grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to characterize distinct subpopulations of dopamine neurons in the ventral tegmental area (VTA) and examine their unique responses to cocaine and fentanyl. Through single-nucleus RNA sequencing and fluorescent in situ hybridization techniques, the research will identify molecular markers that distinguish dopamine-only and dopamine-glutamate...
- This federal Project Grant award of $201,250 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research on the synaptic organization of cholinergic interneurons in the nucleus accumbens region of the brain. The study, conducted by New York University (NYU), aims to characterize the diverse excitatory and inhibitory inputs that contact these interneurons and influence their firing patterns. The research combines...
This federal Project Grant award of $613,786.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is supporting research to elucidate the molecular, cellular, and physiological consequences of D1 dopamine receptor (D1DR) signaling from both the plasma membrane and Golgi compartments in primary medium spiny neurons. The research aims to advance understanding of the role of compartmentalized D1DR signaling in the neurobiology underlying addictive behaviors. The project will utilize state-of-the-art tools such as a light-controlled nanobody recruitment system and photoactivatable constructs to investigate this newly discovered aspect of dopamine signaling. The award began on Sep 1, 2025 and is scheduled for completion by May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $613.8k | 8/27/25 |