Federal Grant Award Summary

The University of Michigan received a $595,171 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded May 1, 2026, with completion targeted for February 28, 2031. This research project investigates the functional anatomy, physiology, and behavioral responses mediated by mu opioid receptor (MOR) signaling on medial thalamic neurons. The research addresses a critical gap in understanding how opioid drugs—while effective for pain relief—lead to misuse and create exaggerated pain perception during withdrawal (opioid withdrawal-induced hyperalgesia). The project will employ behavioral pharmacology, imaging, whole-cell electrophysiology, and optogenetic manipulations in mice to determine which thalamic neurons express MORs, how these neurons respond to conditions causing hyperalgesia, and whether inhibiting these neurons can suppress hyperalgesia.

The research deliverables will advance foundational knowledge of how opioid action in thalamo-cortico-striatal brain circuits affects pain perception and motivation, with implications for understanding both the analgesic and rewarding properties of opioids. This work directly supports NIDA's objective to develop new knowledge and approaches for prevention, diagnosis, and treatment of drug use, misuse, and addiction. The University of Michigan will conduct all research activities at its Ann Arbor, Michigan facilities.