Project Grant R01DA062090

Award Date 8/1/25
Completion Date 4/30/30
Dollars Obligated $781K
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
Buffalo, NY 14214, USA
Similar Awards
This Project Grant award of $250,568.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund a 3-year research project to investigate the neurobiological mechanisms underlying individual and sex differences in emotional cue processing related to addiction and post-traumatic stress disorder. The award recipient, the Regents of the University of Michigan, will use chemogenetic and fiber photometry techniques to gain control...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568 to investigate the mechanisms of dopamine transmission and its role in reward-related behaviors. The award period runs from January 1, 2025 to July 31, 2027. The funded research aims to advance the mechanistic understanding of how dopamine signaling occurs at the subcellular level, given limitations in prior methodologies. The...
This Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $194,375 to The University of Iowa to conduct research on sex-biased, region-specific regulation of dopamine release and clearance. The project aims to investigate how gonadal hormone signaling influences the functional coupling between dopamine transporters and D2 autoreceptors in the nigrostriatal and mesolimbic dopaminergic circuits, and how this translates to...
The National Institute on Drug Abuse (NIDA) awarded a $818,513 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to the Regents of the University of Minnesota to investigate the role of dopamine signaling in the basolateral amygdala in regulating individual differences in reward-based learning strategies and addiction-like behaviors. The 5-year grant, which commenced on Sep 15, 2024, will focus on examining how individual differences in Pavlovian reward learning approaches...
This federal Project Grant award of $400,836, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research at Oberlin College to investigate sex differences in cocaine-induced impulsivity. The key objectives of the research project are to: 1) determine if dopamine D1 receptors contribute to enhanced cocaine-induced impulsivity in female rats, 2) examine if cocaine-induced impulsivity fluctuates across the estrous...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), is focused on validating a novel computational neurobiological model of costly drug-taking behavior centered on the striosomes of the dorsomedial striatum. The $1,766,868 award to the University of Texas at El Paso will use electrophysiology, optogenetics, and advanced modeling techniques to investigate the role of the prelimbic-striosomal and...
This federal Project Grant award of $811,112 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports research by the University of California, San Francisco (UCSF) to investigate the brain networks and neural signaling mechanisms that underlie sudden "insight" learning of cue-reward associations. The key objectives are to use advanced techniques like two-photon calcium imaging, high-density...
This $2,419,326 Project Grant awarded by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a longitudinal study to investigate neurobehavioral and psychosocial predictors of health risk behaviors (HRBs) in adolescence and young adulthood. The primary awardee, Virginia Polytechnic Institute & State University, will conduct assessments over 15 years to understand brain development and its impact on substance use and...
This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $587,162 to Virginia Commonwealth University to investigate the role of norepinephrine transporter (NET) phosphorylation in amphetamine-induced reward behaviors. The research aims to fill critical gaps in understanding how post-translational modifications to NET, a key mediator of noradrenergic neurotransmission, contribute to the complex...

This Project Grant award of $781,032 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research to understand the interplay between norepinephrine and dopamine circuits in the brain and their role in sex differences related to reward and aversion, including substance use disorders.

Specifically, the research aims to map the anatomical and neurochemical distribution of norepinephrine projections from the locus coeruleus and nucleus of the solitary tract to the ventral tegmental area, and their contribution to dopamine regulation in the ventral striatum of male and female rats. It will also determine the functional role of these norepinephrine signaling pathways in modulating dopamine transmission and associated behaviors, such as anxiety-like/aversion and drug seeking, in a methamphetamine self-administration model. This research is expected to reveal the neurobiological mechanisms underlying catecholamine system interactions and their sex differences, potentially leading to novel treatment strategies for neuropsychological and substance use disorders.

Generated 8/5/25, 4:23 AM