Project Grant R21DA064023

Award Date 6/1/25
Completion Date 5/31/27
Dollars Obligated $201K
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
미국 뉴욕
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This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund a research program that investigates the interplay between drug-induced long-term synaptic proteomic adaptations and the underlying transcriptional responses within the brain's reward regions, specifically the nucleus accumbens. The total funding for this 5-year award is $180,606. The research aims to elucidate the cocaine-induced cell-type and...
This $373,300 Project Grant was awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) federal grant program. The award supports research to investigate the role of the nucleus accumbens (NAc) brain region in learning associations between environmental cues and rewards, which is critical for understanding and potentially treating substance use disorders. The research aims to use optogenetic inhibition and two-photon imaging...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund a $373,181 research project at Miami University to investigate the role of cholinergic interneurons in the ventral tegmental area on opioid-related behaviors. The key objectives of the 3-year project are to determine: 1) whether mu-opioid receptors on cholinergic interneurons participate in opioid reward and withdrawal, and 2) whether these...
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This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $149,284 to the University of Washington to investigate the role of prefrontal cortex pyramidal neuron subpopulations in regulating drug-seeking behavior. The research aims to characterize alterations in the activity of intratelencephalic (IT) and pyramidal tract (PT) neurons in the prelimbic region of the prefrontal cortex during heroin...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $284,040 to the Lieber Institute for Brain Development to conduct research on the molecular mechanisms underlying opioid addiction. The project aims to use integrated single-cell and spatial transcriptomic approaches to map gene expression changes in specific cell populations and projection neurons within the habenula, a key brain region...
This federal Project Grant award of $149,284 from the National Institute on Drug Abuse (NIDA) under CFDA Program 93.279 (Drug Use and Addiction Research Programs) will support research to understand how chronic cocaine use disrupts the neural encoding of aversive stimuli in the brain. The key objectives are to: 1) Define the temporal parameters under which dopamine release modulates the activity of specific neuron populations in the nucleus accumbens, at baseline and in response to aversive...
The National Institute on Drug Abuse (NIDA) awarded a $1,100,864 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to The Trustees of Columbia University in the City of New York, Health Sciences Division, for a 3-year period from September 30, 2024 to September 29, 2027. The grant aims to develop principled techniques for integrating large-scale electron microscopy (EM) datasets on neuronal connectivity with functional and behavioral recordings to build and benchmark...
This $207,910 federal Project Grant award was provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), to the Regents of the University of Michigan. The purpose of this 3-year research project is to examine the contribution of pathway-specific neural activity to individual and sex differences in the attribution of salience to emotional cues, in order to better understand the neurobiology underlying addiction and co-occurring...
This Project Grant award of $613,107 was provided by the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research at the Massachusetts Institute of Technology (MIT) to analyze brain-wide mechanisms of neuroplasticity using advanced imaging tools, with the goal of understanding how neural activity, molecular/cellular processes, and behavior interact over time. The key research activities include: 1) Using...

This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $201,250 to New York University (NYU) to conduct research on the synaptic organization of cholinergic interneurons in the nucleus accumbens of the mouse brain.

The key objectives of this 2-year project are to: 1) use cell-type specific retrograde anatomy to identify which local and long-range brain regions provide inputs to cholinergic interneurons in the nucleus accumbens core; 2) employ slice electrophysiology and optogenetics to characterize how these long-range excitatory and inhibitory inputs influence the firing of cholinergic interneurons; and 3) explore how long-range excitatory inputs engage local GABAergic interneurons that provide feed-forward inhibition onto cholinergic interneurons. This research aims to elucidate how cholinergic interneurons, which play a key role in regulating striatal function and motivated behaviors, integrate diverse synaptic inputs within the nucleus accumbens circuitry. The findings could provide important insights into the disruption of these interneurons in substance use disorders.

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