Project Grant R01DA066149
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the Regents of the University of Michigan $172,144 through the Drug Use and Addiction Research Programs (CFDA 93.279) to support research on optimizing chemical- and light-dependent protein switches for controlling opioid peptide activity with temporal control. The grant, awarded on June 26, 2025, funds research designed to advance understanding of mu opioid receptor (MOR) mechanisms and their role in pain...
- Federal Grant Award Summary The University of Michigan received a $595,171 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded May 1, 2026, with completion targeted for February 28, 2031. This research project investigates the functional anatomy, physiology, and behavioral responses mediated by mu opioid receptor (MOR) signaling on medial thalamic neurons. The research addresses a critical gap in understanding...
- Federal Grant Award Summary The University of Michigan received a $170,744 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective June 17, 2025, with a completion date of December 31, 2025. This research initiative investigates the glucocorticoid receptor (GR) as a neuromolecular mechanism underlying inhibitory control deficits associated with substance use disorder (SUD). The project examines how the GR...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $529,990 to Michigan State University (operating as Henry Ford Health+Michigan State University Health Sciences) on September 15, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and test an adaptive psychological intervention designed to reduce prolonged opioid use among hospitalized patients recovering from musculoskeletal injuries. The intervention employs a tiered approach...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to investigate the role of cholinergic interneurons in the ventral tegmental area on opioid-related behaviors. The $373,181 grant, awarded on July 15, 2024 with a completion date of June 30, 2027, aims to determine whether mu-opioid receptors on cholinergic interneurons contribute to opioid reward, consumption, and withdrawal, and how...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the Regents of the University of Minnesota a $673,724 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective May 1, 2026, through February 28, 2031. This research initiative will investigate how opioid exposure modifies nucleus accumbens microcircuits, with the ultimate goal of reversing or preventing maladaptive neuroplastic changes associated with opioid addiction. The project...
- Federal Grant Award Summary The National Institute on Drug Abuse awarded a Project Grant of $386,301.00 to the Regents of the University of Michigan under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning May 1, 2026 and concluding February 28, 2031. This award supports basic neuroscience research investigating axonal mechanisms that regulate dopamine release in the striatum, with particular focus on understanding how striatal cholinergic interneurons modulate dopaminergic...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a Project Grant totaling $787,594 under the Drug Use and Addiction Research Programs (CFDA 93.279) for research on the cortical mechanisms of opioid reinforcement. The award, effective September 1, 2025, through May 31, 2030, supports a comprehensive research program investigating the molecular, cellular, and circuit-based mechanisms underlying opioid use disorder...
- Federal Project Grant Summary The National Institute on Drug Abuse (NIDA) awarded Oklahoma Medical Research Foundation $648,389 under the Drug Use and Addiction Research Programs (CFDA 93.279) on February 15, 2026, for a project extending through November 30, 2030. The research investigates cell type-specific neurotensin signaling in methamphetamine use disorder through behavioral studies, electrophysiology, and molecular manipulation techniques in genetically-modified mice. The project will...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the Regents of the University of Michigan $325,904 on March 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop machine learning methods for real-time modeling and perturbation of stimulus-shaped neural manifolds. The project, which extends through December 31, 2028, will produce generalizable computational tools designed to construct low-dimensional neural manifolds shaped by...
Federal Project Grant Summary: Ventral Tegmental Area Neuromedin S Expression and Signaling in Opioid Responses Michigan State University received a $495,345 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded June 1, 2026, with completion targeted for March 31, 2031. The research investigates the neurobiological mechanisms underlying opioid addiction by examining neuromedin S (NMS) expression and signaling in ventral tegmental area dopamine neurons—a critical component of the brain's reward circuitry. The project deliverables include basic neuroscience research utilizing novel molecular tools (floxed NMS mice and CRISPR-based viral vectors) to manipulate NMS in cell-, circuit-, and temporally-specific manners, with the objective of defining how NMS signaling in the ventral tegmental area and its receptor (NMUR2) in the nucleus accumbens mediates opioid responses. The research addresses a critical public health need by advancing understanding of addiction mechanisms to support development of non-opioid treatments for opioid use disorder—a major health and economic concern, particularly given the shift from prescription opioids to illicit alternatives such as fentanyl. Products and findings generated through this award are expected to contribute to the national drug abuse research agenda by clarifying how specific neuropeptide systems regulate morphine-induced behavioral responses, including conditioned place preference and locomotor sensitization, thereby providing foundational knowledge for future therapeutic interventions targeting opioid addiction without the abuse potential of opioid medications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $495.3k | 5/18/26 |