Project Grant R01AG103065
- The National Institute on Aging awarded Florida State University $664,279 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate extracellular vesicles derived from induced pluripotent stem cell brain organoids as therapeutic targets for Alzheimer's disease. The research combines human iPSC organoid technology, extracellular vesicle engineering, and animal models to examine how tau, amyloid-beta, and extracellular vesicles interact to trigger pathogenic cascades in...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $454,271 to Florida Atlantic University to investigate the role of amyloid precursor protein (APP) and cholesterol homeostasis in synaptic dysfunction and neurodegeneration related to Alzheimer's disease (AD). The research aims to use human neurons derived from induced pluripotent stem cells (hiNs) to systematically study how mutations affecting APP distribution, trafficking, and interaction...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of South Florida $3.297 million under the Aging Research program (CFDA 93.866) for a four-year project period (September 1, 2025 – August 31, 2029) to develop novel peptidomimetic biomaterials that inhibit amyloid-beta (Aβ42) aggregation in Alzheimer's disease. The research deliverables include the rational design and characterization of structurally related analogues to a lead compound that stabilizes Aβ...
- The National Institute on Aging awarded Florida State University $296,232 on March 15, 2026, under the Aging Research program (CFDA 93.866) to investigate thalamocortical spike dynamics and their role in sleep stability and memory consolidation in Alzheimer's disease. The project uses optogenetics, pharmacology, and electrophysiology in behaving rats to understand how spike dynamics in thalamocortical neurons regulate sleep microarchitecture and stability. A second phase tests whether increasing...
- The National Institute on Aging awarded the University of South Florida $637,745 on September 1, 2026, under the Aging Research program (CFDA 93.866) to explore the role of elevated microglial BIN1 expression in Alzheimer's disease pathophysiology. The research investigates how BIN1, the second most common late-onset Alzheimer's disease susceptibility factor identified through genome-wide association studies, functions in microglia to influence Alzheimer's pathology. Preliminary findings from...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $442,750 to the University of California, Davis on September 1, 2026, under the Aging Research program (CFDA 93.866, assistance type: Project Grant) to investigate galectin-12's role in neuroinflammation and Alzheimer's disease progression. The funded research examines how metabolic stress triggers Alzheimer's disease by enhancing inflammation, with a focus on lipid droplet...
- The National Institute on Aging awarded Emory University $643,613 on April 1, 2026, under the Aging Research program (CFDA 93.866) to discover glycosylation-based disease processes and identify glyco-biomarkers and targets for improving Alzheimer's disease diagnosis, prognosis, and intervention. The recipient will perform innovative research using an integrated platform of intact glycopeptide-based quantitative glycoproteomics and systems biology to elucidate brain glycoproteome alterations in...
- The National Institute on Aging awarded the University of Virginia $583,815 on August 15, 2026, under the Aging Research program (CFDA 93.866) to support research into oligodendrocyte lineage dysfunction during aging and Alzheimer's disease. The project aims to understand how myelin loss—a pathology common to both aging and Alzheimer's disease—develops in the central nervous system and to identify therapeutic targets for cognitive impairment. The research focuses on oligodendrocyte precursor...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $170,668 to the University of California, San Diego on October 24, 2025, under the Aging Research program (CFDA 93.866) to support research into s-nitrosylated phospholipase D3 in Alzheimer's disease pathophysiology. The funded research investigates the mechanistic role of s-nitrosylated phospholipase D3 (SNO-PLD3) in Alzheimer's disease. The work builds on prior mass spectrometry findings that...
- The National Institute on Aging awarded the University of South Florida $3,331,541 on September 22, 2025, under the Aging Research program (CFDA 93.866) to conduct transcriptome-wide mapping of brain N6-methyladenosine (m6A) methylome in Alzheimer's disease. The award runs through May 31, 2030, with place of performance in Tampa, Florida. The research will create the first high-resolution reference map of brain m6A methylome in older adults using novel base-resolution quantitative m6A...
The National Institute on Aging awarded Florida State University $443,060 under the Aging Research program (CFDA 93.866) on September 1, 2026, to investigate the role of gangliosides in amyloid-beta aggregation associated with Alzheimer's disease. The research will employ biophysical experiments, in vitro solution and solid-state NMR techniques, cellular and Golgi toxicity assays, and molecular dynamics simulations to determine how free lipids modulate amyloid-beta aggregation, propagation, and toxicity, and to establish atomic-resolution structures of lipid-assisted amyloid-beta aggregates. Understanding membrane-bound and membrane-unbound lipid contributions to toxic aggregate formation will inform understanding of Alzheimer's disease pathological development. The project runs through June 30, 2031, with performance at Florida State University's Tallahassee, Florida campus.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $443.1k | 8/25/26 |