Project Grant R01AG090809
- The National Institute on Aging awarded Florida State University $443,060 under the Aging Research program (CFDA 93.866) on September 1, 2026, to investigate the role of gangliosides in amyloid-beta aggregation associated with Alzheimer's disease. The research will employ biophysical experiments, in vitro solution and solid-state NMR techniques, cellular and Golgi toxicity assays, and molecular dynamics simulations to determine how free lipids modulate amyloid-beta aggregation, propagation,...
- The National Institute on Aging awarded Florida State University $296,232 on March 15, 2026, under the Aging Research program (CFDA 93.866) to investigate thalamocortical spike dynamics and their role in sleep stability and memory consolidation in Alzheimer's disease. The project uses optogenetics, pharmacology, and electrophysiology in behaving rats to understand how spike dynamics in thalamocortical neurons regulate sleep microarchitecture and stability. A second phase tests whether increasing...
- The National Institute of Neurological Disorders and Stroke awarded Florida State University $448,943 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to engineer and bio-manufacture extracellular vesicles secreted by M2 microglia-like cells derived from human induced pluripotent stem cells for stroke therapy. The research aims to promote neural regeneration in ischemic stroke by developing extracellular vesicles that...
- The National Institute on Aging awarded the University of Florida $5.551 million on July 1, 2026, under the Aging Research program (CFDA 93.866) to identify neural signatures that distinguish early Alzheimer's disease from normal aging. The recipient will record electrical activity from ten brain regions across the lifespan in human tauopathy mouse models (HTAU mice) and wild-type controls (C57BL/6J), computing new electrical oscillatory features called electome factors to distinguish between...
- The Johns Hopkins University was awarded a $2,399,582 Project Grant from the National Institute on Aging (CFDA 93.866 Aging Research) to study extracellular vesicles derived from the brain as potential biomarkers for Alzheimer's disease. The 3-year grant, which begins on September 1, 2023, aims to identify specific cell surface markers and molecular signatures on brain-derived extracellular vesicles that could be used for early disease detection, monitoring, and understanding Alzheimer's...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $454,271 to Florida Atlantic University to investigate the role of amyloid precursor protein (APP) and cholesterol homeostasis in synaptic dysfunction and neurodegeneration related to Alzheimer's disease (AD). The research aims to use human neurons derived from induced pluripotent stem cells (hiNs) to systematically study how mutations affecting APP distribution, trafficking, and interaction...
- The National Institute on Aging awarded the University of South Florida $637,745 on September 1, 2026, under the Aging Research program (CFDA 93.866) to explore the role of elevated microglial BIN1 expression in Alzheimer's disease pathophysiology. The research investigates how BIN1, the second most common late-onset Alzheimer's disease susceptibility factor identified through genome-wide association studies, functions in microglia to influence Alzheimer's pathology. Preliminary findings from...
- The National Institute on Aging awarded the Regenerative Research Foundation $428,175 on February 15, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell (iPSC)-derived three-dimensional vascular microphysiological model for studying cerebral amyloid angiopathy and Alzheimer's disease-related vascular pathology. The recipient will establish a 3D model incorporating microglia and vascular endothelial cells within a microfluidic device to enable...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $522,463 to Mayo Clinic Jacksonville on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate UFM1 as a modifier of tau pathology in Alzheimer's disease and related tauopathies. The research will determine whether changes in the ufmylation cascade represent a universal feature across the tauopathy spectrum, identify the substrates to which UFM1 is conjugated in brain under...
- The National Institute on Aging awarded the University of Florida $422,125 on June 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how pathological tau protein affects RNA translation and neuronal function in tauopathies, including progressive supranuclear palsy and Alzheimer's disease. The research will identify RNA transcripts that bind to tau in primary tauopathies, characterize newly translated proteins in the presence of pathological tau, and examine tau-RNA...
The National Institute on Aging awarded Florida State University $664,279 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate extracellular vesicles derived from induced pluripotent stem cell brain organoids as therapeutic targets for Alzheimer's disease. The research combines human iPSC organoid technology, extracellular vesicle engineering, and animal models to examine how tau, amyloid-beta, and extracellular vesicles interact to trigger pathogenic cascades in neurodegeneration. The work uses innovative three-dimensional models composed of dorsal and ventral brain organoids with microglia and includes proteomics and microRNA profiling to evaluate the therapeutic benefits of extracellular vesicles in addressing tau- and amyloid-beta-related phenotypes. The research also evaluates how susceptible loci for late-onset Alzheimer's disease, particularly those expressed in microglia, participate in disease mechanisms. Florida State University's Sponsored Research Administration Division serves as the recipient. Place of performance is Tallahassee, Florida. The project runs through August 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $664.3k | 9/1/26 |