Project Grant R01AG092406
- Federal Grant Award Summary Emory University received a $657,222 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective February 15, 2026, through January 31, 2031. The award funds research directed at defining pathological roles of novel protein interactions with amyloid in Alzheimer's disease (AD). The research will generate scientific knowledge regarding mechanisms of amyloid-related neurodegeneration by testing the Amyloid Scaffold...
- Federal Grant Award Summary Emory University received a $651,466 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 15, 2026, through November 30, 2030. The award supports research investigating the role of promyelocytic leukemia protein (PML) in oxidative stress and Alzheimer's disease pathogenesis. The research focuses on understanding how PML modulates microRNA (miRNA) biogenesis through the microprocessor complex,...
- Federal Grant Award Summary Emory University received a $1,027,977 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded June 1, 2025, with a completion date of March 31, 2030. This award supports research investigating cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and Alzheimer's disease and related dementias (AD/ADRD). The research addresses significant gaps in existing...
- Federal Project Grant Award Summary Emory University received a $147,656 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), with an award date of March 11, 2025 and project completion date of September 29, 2025. The grant supports the development of the first human locus coeruleus (LC) organoid model to advance understanding of Alzheimer's disease (AD) pathology. The research addresses a critical gap in AD knowledge by utilizing...
- Federal Project Grant Award Summary Emory University received a $149,190 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded August 6, 2026, with completion targeted for February 28, 2029. The funded research project, "Neuromelanin Formation and Toxicity in the Locus Coeruleus: The Role of Norepinephrine Metabolism," investigates the selective vulnerability of the locus coeruleus (LC) brain region in Alzheimer's disease (AD). The...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $509,413 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 15, 2025, with completion targeted for May 31, 2030. The award funds research investigating epitranscriptomic regulation of microglia in Alzheimer's Disease (AD), specifically examining how adenosine methylation (m6A) modifications control microglial cell...
- Federal Grant Award Summary The National Institute on Aging awarded Columbia University's Health Sciences Division a Project Grant totaling $529,744 under the Aging Research program (CFDA 93.866) to conduct biomedical research investigating the progression of Alzheimer's disease pathology. The award, effective February 15, 2026, through January 31, 2031, supports research aimed at understanding why the entorhinal cortex (EC) is uniquely vulnerable to early tauopathy and neuroinflammation in...
- Federal Grant Award Summary The University of South Florida received a $3.297 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2029. This award supports the development of novel peptidomimetic biomaterials designed to inhibit amyloid-beta (Aβ42) aggregation as a therapeutic intervention for Alzheimer's disease. The research builds upon preliminary findings demonstrating that...
- Federal Grant Award Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded The Washington University a Project Grant of $2,631,670 effective September 1, 2025, through August 31, 2029. This research initiative investigates age-related deficits in episodic memory for both the content and structure of naturalistic events, with particular focus on understanding memory loss mechanisms in aging and Alzheimer's disease (AD). The project will deliver...
- Federal Project Grant Award Summary The J. David Gladstone Institutes received a $1,583,207 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 1, 2025, through March 31, 2030. The research project, titled "Targeting NELL2 and GABAergic Dysfunction to Mitigate APOE4-Driven Pathogenesis in Alzheimer's Disease," focuses on understanding the mechanisms by which apolipoprotein E4 (APOE4)—the major genetic risk factor for...
Emory University's Office of Sponsored Programs received a $643,613 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective April 1, 2026, through January 31, 2031. The award funds innovative research to discover glycosylation-based disease processes and identify glyco-biomarkers and therapeutic targets for improving Alzheimer's disease (AD) diagnosis, prognosis, and treatment. The project employs a transformative platform integrating intact glycopeptide-based quantitative glycoproteomics and systems biology to conduct large-scale analysis of protein glycoforms and site-specific glycan modifications in human patient specimens, addressing a critical gap in understanding how glycoproteostasis dysregulation contributes to AD development and progression. The research outputs will advance knowledge of brain glycoproteome alterations in Alzheimer's disease and uncover disease-associated glycoform changes and mechanisms. This work directly supports the NIA's mission to prevent and treat Alzheimer's disease and related dementias through biomedical research directed toward understanding age-related diseases. The project leverages Emory University's established capabilities as a premier academic medical research center with extensive experience executing complex biomedical and neuroscience research initiatives funded by federal agencies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $643.6k | 3/23/26 |