Project Grant R01AG095602
- This Project Grant award of $852,273 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) aims to investigate the role of RNA modifications in Alzheimer's disease (AD). The project will: (1) create a comprehensive atlas of N6-methyladenosine (M6A) and pseudouridine (Ps) modifications in human brain cells across multiple ancestries, and map their quantitative trait loci; (2) integrate this data with other molecular QTL and AD genome-wide association study data...
- This federal Project Grant award of $839,933 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The research will systematically map m6A RNA modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglia models. The project will also...
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,041,438 to develop new computational tools and biomarkers for Alzheimer's disease. The University of Miami will aggregate and analyze DNA methylation datasets to identify age-associated epigenetic changes related to aging and Alzheimer's progression. Researchers will create a searchable web interface to disseminate findings on the role of DNA...
- This Project Grant award from the National Institute on Aging (NIA) under the Aging Research Program (CFDA 93.866) provides $805,573 to The Regents of the University of California, San Francisco (UCSF) to support research on the impact of RNA modifications, specifically N6-methyladenosine (m6A), in Alzheimer's disease (AD) and related tauopathies. The key objectives are to characterize changes in m6A-modified RNAs and their downstream functional consequences in post-mortem brain tissue from AD...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to elucidate the role of RNA modification, specifically N6-methyladenosine (m6A), in the pathogenesis of Alzheimer's disease (AD) and related tauopathies. The total award amount is $745,092 over the project period from January 1, 2025 to November 30, 2029. The key objectives are to: 1) decode the epitranscriptomic profiles impacted by tau pathology using m6A DART-seq; 2) determine the role of RNA...
- The University of Massachusetts Medical School (UMass Medical) was awarded a $1,507,500 Project Grant from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to conduct a study on spatial single-cell analysis of somatic mutations in the human brain during aging and neurodegeneration. The goal is to develop and apply new single-cell whole-genome sequencing methods to study somatic mutations in neurons from late-stage Alzheimer's disease and...
- This $287,118 Project Grant was awarded on September 1, 2023 by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) grant program. The grant will fund the development of techniques to use deep transfer learning and multimodal data, including brain MRIs, genetic information, and cognitive tests, to enable the early detection and forecasting of Alzheimer's disease progression. The University of Massachusetts (UMass), as the prime awardee, will create an end-to-end...
- This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $509,413 to Duke University to conduct research on the "Epitranscriptomic Regulation of Microglia in Alzheimer's Disease". The project aims to elucidate the factors controlling the transition of microglial cells from a resting to activated state, and how microglial function is regulated during the pathogenesis of Alzheimer's disease. This research seeks to enhance understanding of...
- The U.S. National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded a $1,459,072 Project Grant to the J. David Gladstone Institutes in San Francisco, California to conduct research aimed at monitoring and restoring cell-type selective inhibitory deficits and circuit dysfunction in humanized Alzheimer's disease models. The project will leverage dual cell-type-specific enhancer-AAVs to independently monitor and manipulate parvalbumin and somatostatin...
This $848,286 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) will fund a study to map the brain's N6-methyladenosine (m6A) methylome in Alzheimer's disease. The goal is to create a high-resolution reference map of m6A sites in the brains of older adults, identify m6A alterations associated with Alzheimer's and its endophenotypes, and elucidate how m6A dysregulation may contribute to Alzheimer's pathogenesis. The 5-year project will leverage a large collection of postmortem brain tissue samples from the dorsolateral prefrontal cortex. The study will utilize novel transcriptome-wide m6A profiling technologies recently developed by the researchers. The findings aim to enhance understanding of the role of m6A RNA modifications in Alzheimer's disease pathology and progression.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $848.3k | 9/18/25 |