Project Grant R01AG102936
- The National Institute on Aging awarded Michigan State University (doing business as Henry Ford Health+Michigan State University Health Sciences) $314,000 on April 1, 2026, under the Aging Research program (CFDA 93.866) to optimize and validate detection and modeling of the vascular and glymphatic systems in cerebral waste clearance using superparamagnetic iron oxide-enhanced susceptibility weighted imaging (SPIO-SWI), and to investigate cerebral waste clearance changes during Alzheimer's...
- The National Institute on Aging awarded the Regents of the University of Michigan $116,079 on September 1, 2026, under the Aging Research program (CFDA 93.866) to assess how multilevel life course socioeconomic conditions relate to disparities in Alzheimer's disease and related dementias. The project examines socioeconomic trajectories at both individual and neighborhood levels in relation to cognitive decline, dementia incidence, and brain health indicators including structural magnetic...
- The National Institute on Aging awarded the Regents of the University of Michigan $654,999 on September 1, 2026, under the Aging Research program (CFDA 93.866) to assess cognitive functioning in the National Monitoring the Future (MTF) Panel Study. The award funds the addition of web-based cognitive measures to the MTF Panel, a nationally representative longitudinal study of high school seniors followed since 1975. The cognitive measures—assessing memory, numeracy, executive functioning, word...
- The National Institute on Aging awarded the Regents of the University of Michigan $758,442 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and test two pragmatic interventions aimed at increasing brain donation among older adults at risk for Alzheimer's disease and related dementias. The project, "The Brain Gifting Counseling Program: A Novel Peer-Professional Intervention to Enhance Brain Donation Among Older Adults at Risk for Alzheimer's Disease and...
- The National Institute on Aging awarded the Regents of the University of Michigan $284,108 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how mechanical changes in the aging brain affect microglial function and Alzheimer's disease progression. The project explores the relationship between age-related mechanical alterations in brain tissue—specifically decreased stiffness and increased viscoelasticity resulting from reduced tissue connectivity—and microglial...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the Regents of the University of Michigan $779,211 on September 2, 2026, under the Aging Research program (CFDA 93.866) to investigate the health, functional, and financial impacts of Medicaid disenrollment on adults ages 50-64 in Michigan. The research team will conduct a longitudinal two-wave survey of Michigan Medicaid enrollees ages 50-64 to evaluate how disenrollment affects insurance coverage,...
- The National Institute of Neurological Disorders and Stroke awarded Michigan State University (doing business as Henry Ford Health+Michigan State University Health Sciences) $715,376 on August 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate a rat model of dementia with Lewy bodies. The research combines the TG344-19 transgenic rat model of Alzheimer's disease with intrastriatal injections of...
- Federal Grant Award Summary Michigan State University's Henry Ford Health+Michigan State University Health Sciences partnership received a $2.86 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded on August 15, 2025, with a completion date of July 31, 2029. This research project aims to model the effects of cadmium exposure on Alzheimer's disease (AD) pathology and neurodegeneration through a multi-principal investigator approach...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $298,419 to the Regents of the University of Michigan on February 1, 2026, under the Aging Research program (CFDA 93.866, Assistance Listing Project Grant R01AG097771). The recipient will develop advanced statistical and computational methods for analyzing immune cell data to enhance understanding of the immune system's role in aging and age-related diseases. The project addresses analytical...
- The National Institute on Aging awarded the Regents of the University of Michigan $1,703,843 on April 1, 2026, under the Aging Research program (CFDA 93.866) to generate prospective environmental chemical exposure data from stored biospecimens in the Health and Retirement Study cohort and examine associations between chemical and social exposures and Alzheimer's disease and related dementias (ADRD). The project performs state-of-the-art non-targeted analysis to measure chemical levels...
The National Institute on Aging awarded Michigan State University (doing business as Henry Ford Health+Michigan State University Health Sciences) $624,029 on September 1, 2026, for research into dimensional complexity as a biomarker for cognitive resilience in aging and dementia under the Aging Research program (CFDA 93.866). The project will develop and clinically validate dimensional complexity (DC), a novel resting-state fMRI biomarker that quantifies dynamic brain activity organization, to predict cognitive resilience and identify individuals likely to remain cognitively stable. The work leverages two cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Risk Reduction for Alzheimer's Disease (RRAD) clinical trial. Specific aims include developing and validating a DC-based prognostic model in ADNI and RRAD, testing DC as a predictive biomarker to identify RRAD participants most likely to benefit from intensive vascular risk reduction and exercise interventions, determining biological underpinnings by identifying physiological modulators including plasma biomarkers and structural brain integrity, and developing and releasing a containerized DC toolbox for reproducible computation. Research is performed in East Lansing, Michigan, with a period of performance from September 1, 2026, through June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $624.0k | 9/1/26 |