Project Grant R03AG098231
- Federal Project Grant Award Summary The National Institute on Aging awarded a $3,062,355 Project Grant to Henry Ford Health + Michigan State University Health Sciences (UEI: NH77YPDEGG84) under the Aging Research program (CFDA 93.866) on September 15, 2025, with a project completion date of August 31, 2029. The award supports research to optimize and validate detection of microvessels within the cerebral vascular, glymphatic, and meningeal lymphatic systems using superparamagnetic iron oxide...
- Federal Project Grant Award Summary The University of Michigan received a $442,695 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded May 1, 2025 and scheduled for completion January 31, 2027. The research aims to develop immunocytokines—monoclonal antibodies (MAbs) or bispecific antibodies (BAbs) fused to macrophage colony-stimulating factor (M-CSF)—to enable selective, sustained, and localized activation of parenchymal border...
- Federal Grant Award Summary The University of Michigan, through its Office of Research and Sponsored Projects, received a $655,198 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective March 1, 2026, with completion targeted for November 30, 2030. This research initiative focuses on developing and validating a novel therapeutic delivery technology for non-invasive modulation of microglia gene expression. The project addresses...
- Federal Grant Award Summary The National Institute on Aging awarded The Leland Stanford Junior University a $165,888 Project Grant on August 15, 2025, under the Aging Research program (CFDA 93.866) to conduct research on neuroimaging and genetics of the glymphatic system in Alzheimer's disease through May 31, 2030. The research will deliver novel, non-invasive diagnostic markers characterizing the brain's glymphatic system—its waste clearance mechanism—by combining three complementary...
- Federal Grant Award Summary Michigan State University received a $369,654 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective May 15, 2025 through February 28, 2030. This research initiative examines cultural variation in how spousal depressive symptoms impact Alzheimer's disease (AD) prevalence and physical health outcomes across the second half of life. The project leverages longitudinal panel data from the International Sister...
- Federal Project Grant Award Summary The University of Michigan, Office of Research and Sponsored Projects, received a $257,040 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) on June 15, 2025, with a completion date of March 31, 2030. This award supports a research initiative focused on understanding the role of Alzheimer's Disease (AD) pathology in Mild Behavioral Impairment (MBI), addressing the significant public health challenge...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $284,108 project grant to the Regents of the University of Michigan, effective January 1, 2026 through December 31, 2027, under the Aging Research program (CFDA 93.866). This grant funds a two-year research initiative investigating how mechanical changes in the aging brain—specifically decreased stiffness and increased viscoelasticity—affect microglial function and contribute to Alzheimer's disease (AD)...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Michigan a $303,449 project grant effective June 1, 2025, through May 31, 2027, under the Aging Research program (CFDA 93.866) to investigate the genomic impact of transposable elements (TEs) in Alzheimer's disease and related dementias (ADRD). The research will leverage large-scale genomic datasets and clinical information from major Alzheimer's disease cohorts to overcome analytical challenges...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Henry Ford Health + Michigan State University Health Sciences a Project Grant totaling $2,862,804 under the Aging Research program (CFDA 93.866) on August 15, 2025, with a completion date of July 31, 2029. This research initiative investigates the mechanisms by which cadmium exposure—a toxic heavy metal to which up to 20% of Americans are exposed through contaminated food and smoking—contributes to the pathology...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the Regents of the University of Michigan a Project Grant of $1,402,051 under the Aging Research program (CFDA 93.866), effective August 1, 2025, through April 30, 2030. This award supports the development of novel multimodal machine learning models designed to identify latent factors associated with cognitive resilience in Alzheimer's disease (AD) and related dementias. The research will employ variational autoencoder...
The National Institute on Aging awarded a $314,000 Project Grant to Michigan State University (in partnership with Henry Ford Health) under the Aging Research program (CFDA 93.866) for the period April 1, 2026 through March 31, 2028. This Small Research Grant Program for the Next Generation of Researchers in Alzheimer's Disease and Alzheimer's Disease and Related Dementias (AD/ADRD) focuses on optimizing and validating advanced magnetic resonance imaging (MRI) detection methods to model the vascular and glymphatic systems involved in cerebral waste clearance (CWC) using superparamagnetic iron oxide (SPIO)-enhanced susceptibility weighted imaging (SPIO-SWI) techniques. The research deliverables include development and validation of highly sensitive MRI methodology to detect cerebral microvessels and investigate how CWC changes in vascular and glymphatic systems during AD progression, with particular emphasis on understanding the relationship between impaired waste clearance and beta-amyloid (Aβ) accumulation around blood vessels. Preliminary data from rat models of AD indicate that clearance of contrast agents decreases with disease severity, providing the foundation for this investigation into the mechanistic interactions among cerebral blood vessel changes, perivascular space alterations, and functional deficits during AD development.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $314.0k | 3/19/26 |