Project Grant RF1AG090456
- This federal Project Grant award of $822,643.00, awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund a research project to investigate how chronic exposure to common environmental neurotoxicants like lead, cadmium, and arsenic impact brain aging and the risk of late-onset Alzheimer's disease (LOAD). The researchers at Boston University Medical Campus, the prime awardee, will use innovative mouse models developed by the Model-AD Consortium to study...
- This federal Project Grant award, funded by the National Institute on Aging (CFDA 93.866 Aging Research), aims to identify links between pesticide exposure and markers of Alzheimer's disease and related dementias (ADRD) among U.S. farmers. The $2,368,557 award, with a project period from March 2025 to January 2030, will leverage 30 years of data from the Agricultural Health Study (AHS) and the Pesticides and Sense of Smell (PASS) sub-cohort to pursue four specific aims: 1) identify pesticides...
- This $4,260,300 project grant from the National Institutes of Health's National Institute on Aging will fund research under the Aging Research program (CFDA 93.866) to investigate the association between in utero environmental exposures and life-course cognition and prodromal Alzheimer's disease in midlife. The Public Health Institute will leverage existing data and biospecimens from the 50+ year follow up of the Child Health and Development Studies birth cohort to conduct targeted and...
- The Project Grant titled "The Role of Neighborhood Social Exposome Dynamics in Risk and Resilience to Alzheimer's Disease and Related Dementias" was awarded by the National Institute on Aging (NIA), under CFDA Program 93.866 - Aging Research. The $3,039,714 grant, with a performance period from September 15, 2025 to September 14, 2029, will investigate the pathways between 30 years of neighborhood-level social exposome change, individual modifiable Alzheimer's disease and related...
- This $3,264,260 Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 (Aging Research) aims to determine whether olfactory impairment caused by exposure to ambient fine particulate matter (PM2.5) pollution is a causal factor in the development of late-onset dementia, including Alzheimer's disease. The award will fund a comprehensive research project conducted by the University of Maryland, Baltimore to investigate the role of the cGAS/STING/IKK2/NF-κB inflammatory...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by the Henry Ford Health and Michigan State University Health Sciences partnership to optimize and validate the detection of microvessels in the cerebral vascular, glymphatic, and meningeal lymphatic systems using superparamagnetic iron oxide (SPIO)-enhanced susceptibility weighted imaging (SWI). The $3,062,355 award will be used to investigate cerebral waste clearance in the...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
- The Project Grant award of $3,133,754 from the National Institute of Environmental Health Sciences (NIEHS, CFDA 93.113 Environmental Health) aims to comprehensively assess the exposome (a person's cumulative lifetime exposures) and epigenome in a Michigan cohort to determine how they associate with amyotrophic lateral sclerosis (ALS) risk and survival. The research, conducted by the Regents of the University of Michigan, seeks to gain insight into ALS disease etiology by examining the...
- This $2,107,715 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the Regents of the University of Michigan aims to determine the extent to which exposure to hurricanes affects mortality among older adults living with Alzheimer's disease and related dementias (ADRD). The project will: 1) Examine all-cause mortality following hurricane exposure and identify associated causes of death among the ADRD population; 2) Determine the living environments...
- This $6,925,230 Project Grant award from the National Institutes of Health (NIH) National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project at The Trustees of Columbia University in the City of New York to develop a "Multi-Organ Chart of Personalized Susceptibility to Alzheimer's Disease and Aging." The overarching goal is to use large-scale multi-omics, multi-organ biomedical data, advanced artificial intelligence/machine learning, and computational...
This $2,862,804 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support a collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences to investigate the effects of cadmium exposure on Alzheimer's disease pathology and neurodegeneration. The project aims to utilize both C. elegans nematode models and transgenic rodent models to identify the mechanisms by which cadmium exposure alters amyloid-beta and tau-induced neurodegeneration. The award, running from August 15, 2025 to July 31, 2029, will fund research to advance scientific understanding of how environmental toxicant exposure may contribute to the progression of Alzheimer's disease and related neurodegenerative disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.9m | 8/4/25 |