This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $223,622 to The University of Texas Health Science Center at San Antonio to conduct research on the pathogenic effects of senescent cells on their microenvironments and their role in human brain aging. The study aims to identify molecular changes in the microenvironment of senescent neurons compared to healthy neurons, as well as their specific role in neuronal death in brain aging and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $433,824 to the J. David Gladstone Institutes in San Francisco, CA to investigate how the Alzheimer's disease risk factor APOE4 disrupts the maturation and integration of adult-born dentate granule cells in the hippocampus. The research aims to elucidate the underlying transcriptomic changes and electrophysiological alterations that lead to hyperexcitability in these neurons, with the...
This $205,619 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research program) to the University of Washington aims to improve experimental platforms for studying human brain aging and identify pathways that may be developed therapeutically for neurodegenerative disorders and longevity.
The key objectives are to apply explainable artificial intelligence (XAI) methods to human brain omics datasets to identify molecular drivers of brain aging, and then manipulate...
This federal Project Grant award for $2,319,456 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to the University of California, San Diego (UCSD). The funding will support the development and characterization of brain organoid models derived from human induced pluripotent stem cells (hiPSCs) to understand the underlying mechanisms and endotypes of Alzheimer's disease (AD). Specific objectives include: 1) Deriving isogenic hiPSC lines with...
This $174,242 Project Grant award under the National Institute on Aging's Aging Research program (CFDA 93.866) aims to study the prefrontal microcircuit changes in the brain during healthy aging and Alzheimer's disease progression. The project will integrate empirical in vivo calcium imaging recordings, computational simulation modeling, and calcium imaging-based neural decoding methods to determine the impacts of normal aging and Alzheimer's-related pathologies on the prefrontal cortex...
This $131,027 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by The Leland Stanford Junior University to study neuronal proteostasis, the maintenance of protein health, during brain aging and Alzheimer's disease (AD). The principal investigator will use a novel in vivo protein tagging technique called BONCAT to examine changes in neuronal protein turnover in young versus aged and AD mouse models. The project aims to characterize...
This $169,560 federal Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) will support research to understand and address inhibitory interneuron dysfunction in Alzheimer's disease (AD) and related dementias. The key objectives are to: 1) Catalog aberrant gene expression in interneurons from human AD brain tissue to identify therapeutic targets; 2) Characterize and correct inhibitory dysfunction in AD-derived interneuron cultures; and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $254,250 to New York University School of Medicine to conduct a multiscale modeling study of brain aging and Alzheimer's disease (AD). The key objectives are to:
Develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI techniques to examine the roles of neuroinflammation and neurodegeneration. This will involve creating a large dataset by unifying...
This federal Project Grant award, funded by the National Institute on Aging (CFDA 93.866 Aging Research), aims to investigate human-specific vulnerabilities and compensatory adaptations in midbrain dopaminergic neurons. The $866,764 award will enable an interdisciplinary research approach, including the use of stem cell-derived organoids, primary tissue analysis, machine learning, and CRISPR functional validation.
The key objectives are to determine the genomic elements and genetic changes...
This federal Project Grant award of $522,500 from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Salk Institute for Biological Studies will fund research to investigate the role of astrocytes, a type of non-neuronal brain cell, in age-related motor and cognitive decline. The key objectives are to determine if the transcription factor STAT1 drives aging-related changes in cerebellar astrocytes, and to elucidate the signaling cues that lead to STAT1 upregulation in the...
This $126,956 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to identify the molecular mechanisms underlying the conversion of glial cells into functional neurons in the aged adult brain. The principal investigator, utilizing a therapeutically viable approach to generate new neurons, will leverage a combination of single nuclear sequencing and advanced spatial transcriptomics (MERFISH) to map the pathways of glial-to-neuron identity conversion. This work aims to determine if this neuron generation process can be harnessed to replace neurons lost due to aging, injury, or neurodegenerative diseases like Huntington's and frontotemporal dementia. The research will be conducted at the University of California, San Diego over the award period from April 1, 2025 to February 28, 2027.