Project Grant RF1AG090599
- This federal Project Grant award of $3,230,150.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the University of Kansas Center for Research Inc. investigating the relationship between neuronal activity, synaptic abnormalities, and mitochondrial function in Alzheimer's disease. The study aims to determine whether modulating these factors could enhance neural plasticity in amyloidosis using mouse models. Through a combination of in vivo and ex vivo...
- This Project Grant award from the National Institutes of Health (NIH), under the Aging Research program (CFDA 93.866), provides $610,836 to The Broad Institute, Inc. to conduct research on mitonuclear interactions in aging and neurodegenerative diseases like Alzheimer's. The project aims to leverage recent technological advances, including mitochondrial DNA editing and large-scale biobank analyses, to systematically investigate how mitonuclear interactions contribute to aging and...
- This Project Grant award, with a total funding amount of $878,190.00, was provided by the National Institute on Aging (part of the U.S. Department of Health and Human Services) under the Aging Research federal grant program (CFDA 93.866). The grant is supporting research by the Scripps Research Institute in California to investigate a "druggable mito-nuclear feedback mechanism" that can preserve mitochondrial and synaptic function in aging and age-related dementias like Alzheimer's...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,027,220 to the Oklahoma Medical Research Foundation (OMRF) to investigate the role of the Major Histocompatibility Complex I (MHC-I) in regulating microglial function during aging and Alzheimer's disease. The research aims to determine if MHC-I expression modulates microglial reactivity and phagocytic phenotypes, impacts prodromal Alzheimer's disease symptoms and disease progression, and...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $781,008.00 to investigate the role of tRNA modifications in regulating mitochondrial function and the mitochondrial proteome in Alzheimer's disease and related disorders (AD/ADRD). The research aims to identify genetic mutations in mitochondrial DNA, tRNA genes, and genes encoding the mitochondrial proteome that are associated with AD status, using large-scale whole genome sequencing data from...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $308,000 to the Regents of the University of Minnesota to investigate the impact of amyloid-beta 42 (Aβ42) on mitochondrial liquid-liquid phase separation and its effects on mitochondrial dysfunction in Alzheimer's disease. The primary goals are to: (1) Investigate the impact of Aβ42 on mitochondrial ribonucleoprotein granule dynamics in mitochondria; and (2) Use optogenetic control of Aβ42...
- This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
- This federal Project Grant award of $2,316,710 from the National Institute on Aging (CFDA 93.866 Aging Research) aims to develop magnetogenetic techniques for manipulating the activity of specific brain cell types implicated in the onset and progression of Alzheimer's disease (AD). The research will focus on using a magnetogenetic tool called FERIC (Ferritin Iron Redistribution to Ion Channels) in combination with enhancer AAV vectors to non-invasively control the activity of AD-vulnerable...
- This federal Project Grant award of $2,631,670 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a research initiative at The Washington University to investigate age-related deficits in episodic memory. The project aims to determine how aging distinctly affects the content and structure of memory representations, and how this relates to dysfunction in different brain networks based on susceptibility to Alzheimer's disease pathology. The research will utilize plasma...
This federal Project Grant award of $2,602,940 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research conducted by the Oklahoma Medical Research Foundation (OMRF) to investigate the role of mitochondrial AMPK signaling in neurons and its impact on dendritic spine maintenance. The research aims to determine the molecular composition and dynamics of mitochondrial-localized AMPK complexes (mitoAMPK) in Alzheimer's disease (AD) neurons, as well as establish mitoAMPK's role in dendritic structure and function using in vivo techniques. The award period runs from September 15, 2025 through August 31, 2029. This research seeks to provide insights into how AMPK activity at the mitochondrial surface contributes to the synaptic deficits observed in AD, with the potential to inform future therapeutic interventions targeting mitochondrial dysfunction.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.6m | 9/10/25 |