The National Institutes of Health's National Institute on Aging awarded a $5,063,226 Project Grant to Brigham and Women's Hospital Inc. under the Aging Research program (CFDA 93.866) for the period of September 1, 2022 through August 31, 2025. The grant funds research to analyze the functional role of glial cells in tauopathy and Alzheimer's disease. Researchers will use genetic approaches in Drosophila to identify glial proteins and pathways that influence tau neurotoxicity in aging adult fly...
This $239,122 federal Project Grant, awarded by the National Institute on Aging (CFDA 93.866 - Aging Research), will support a research initiative led by Yale University to leverage computational and experimental approaches to study the impacts of aging processes and Alzheimer's disease (AD) genetic risk factors on gene expression and cellular function in the brain. The project has two main objectives: 1) develop computational models to integrate multi-omics data and characterize cell-type...
This federal Project Grant award, valued at $6,226,692.00 and funded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to investigate the role of neuronal hyperexcitability and proteostasis in the progression of Alzheimer's disease (AD). The study aims to track early electrophysiological changes in the locus coeruleus (LC) and hippocampus (HPC) as key brain regions impacted by the accumulation of beta-amyloid and tau proteins. The research seeks to understand...
This federal Project Grant award, funded by the Department of Health and Human Services' National Institute on Aging under the Aging Research program (CFDA 93.866), supports research into the regulation of entorhinal cortex layer II vulnerability in Alzheimer's disease. The $4,324,857 award to Trustees of Boston University Medical Campus, which spans from August 1, 2024 to April 30, 2029, will investigate a microRNA called miR-129-2 that appears to modulate Alzheimer's pathology in the...
This $519,750 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 2-year research study by the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco. The study aims to explore the underlying molecular mechanisms by which reducing levels of the tau protein can prevent or diminish excitation/inhibition imbalance and network hyperexcitability in the brain. This imbalance has been observed in various...
The National Institutes of Health (NIH) National Institute on Aging (NIA) awarded a $3,537,652 project grant (CFDA 93.866 - Aging Research) to the HudsonAlpha Institute for Biotechnology in Huntsville, AL. The funding will support a 5-year research project to comprehensively identify transcriptional regulators that control expression of the MAPT gene, which encodes the tau protein associated with neurodegenerative diseases. The key objectives are to: 1) Use CRISPR screening to identify...
Brown University received a $320,082.72 project grant award from the National Institutes of Health's National Institute on Aging on January 15, 2021 to complete work by August 15, 2021. The grant supports research to characterize the transcriptome and epigenome of genetic models of Alzheimer's disease in Drosophila melanogaster. Using computational biology approaches and next-generation sequencing techniques, the researchers will identify characteristic transcriptional and chromatin state...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $528,876 to Emory University to investigate the cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD). The project aims to develop new analytical tools that can leverage genomic data from multiple tissues to identify additional AD risk genes and better understand their underlying molecular...
The National Institute on Aging (NIA), part of the Department of Health and Human Services National Institutes of Health, awarded a $3.37 million Project Grant to The University of Texas at Arlington to develop an individualized deep connectome framework for Alzheimer's disease and related dementias (ADRD) analysis. The three-year grant, awarded on August 18, 2022 under the NIA's Aging Research program (CFDA 93.866), will support research to discover and identify individualized...
This Project Grant award, valued at $10,847,672 and funded by the National Institute on Aging's Aging Research program (CFDA 93.866), supports research on the mechanisms underlying cerebral amyloid angiopathy (CAA) and its relationship to Alzheimer's disease pathology. The primary awardee, J. David Gladstone Institutes, will conduct comprehensive studies using human postmortem brain samples, single-cell genomics, and mouse models to elucidate how microglia regulate the balance between vascular...
This Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, provides $3,018,210 to Baylor College of Medicine under the Aging Research program (CFDA 93.866). The grant funds research to functionally dissect a promising transcriptional regulatory network linked to glutamate excitatory signaling that is downregulated in Alzheimer's disease and enriched for suppressors of neurodegeneration. Researchers will perform genetic manipulations in Drosophila models to screen hundreds of network genes as enhancers or suppressors of tau- or amyloid-beta-induced neuronal dysfunction. Promising results will be validated and causal human gene expression impacts confirmed. Additional work will examine genetic manipulations of network drivers like GRIN2B in Drosophila and mouse models of excitotoxic neuronal injury. The project aims to map the molecular architecture of Alzheimer's disease excitotoxicity and identify vulnerable nodes for potential pharmacologic reprogramming to preserve synaptic health.