Project Grant R01AG094959
- The National Institute on Aging, a component of the Department of Health and Human Services, awarded The Trustees of the University of Pennsylvania $644,239 on August 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of activin type II receptor signaling in muscle physiology, weight loss, and aging. The recipient will conduct research examining muscle loss associated with GLP-1 and GIP receptor agonist treatment, particularly in aged populations where even modest...
- The National Institute on Aging awarded Arizona State University $436,228 on June 1, 2026, under the Aging Research program (CFDA 93.866) to evaluate the impact of glucagon-like peptide-1 receptor agonists on sarcopenia in older adults. The research project will measure muscle mass and the mechanisms regulating muscle mass—including muscle protein synthesis and breakdown—using stable isotope tracer methodologies in older patients before and six months after GLP-1 RA treatment. The study will...
- The National Institute on Aging awarded the University of Florida $540,345 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research into a metabolic sensor-driven metabolite repair system that maintains muscle stem cell homeostasis. The research addresses loss of skeletal muscle stem cell function as a central driver of impaired regeneration, progressive muscle wasting, and frailty in aging, muscular dystrophies, and metabolic diseases. The project investigates...
- The National Institute on Aging awarded Wake Forest University Health Sciences $1.31 million on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the synergistic effects of unacylated ghrelin and endurance exercise on sarcopenia and mobility loss in older adults. The research combines unacylated ghrelin (UNAG) administration with endurance exercise training to enhance mitochondrial bioenergetics and preserve neuromuscular junction integrity in aging mice....
- The National Institute for Minority Health and Health Disparities awarded the University of Florida $734,785 on September 1, 2026, under the Minority Health and Health Disparities Research program (CFDA 93.307) to conduct a randomized controlled trial examining lifestyle strategies for preserving muscle mass and reducing cardiovascular risk in adults with obesity who initiate GLP-1 receptor agonist therapy. The trial will enroll 670 adults with obesity (BMI 30 or BMI 27 with comorbidity) from...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $749,481 to Pennington Biomedical Research Center on January 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a 12-week randomized controlled feeding trial testing whether a low-energy-density diet combined with exercise reduces fat mass, improves muscle function, and increases energy deficit in older adults with obesity and insulin resistance. The study enrolls 80 participants over...
- The National Institute on Aging awarded Mayo Clinic $443,850 on March 15, 2026, under the Aging Research program (CFDA 93.866) to study the real-world effects of glucagon-like peptide-1 receptor agonist (GLP-1 RA) medications on older adults. Mayo Clinic will use linked electronic health records from the Rochester Epidemiology Project to analyze age differences in GLP-1 RA response across a population-based cohort of 26,442 persons in the upper midwest. The study will test three primary...
- The National Institute on Aging awarded The Washington University $427,625 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate intramuscular adipose tissue quality and its relationship to muscle weakness in aging. The research addresses the mechanism by which ectopic adipose tissue accumulates within muscle boundaries during aging, impairing muscle contraction through secreted signals. The project tests the hypothesis that intramuscular adipose tissue quality...
- The National Institute on Aging awarded the University of Florida $103,969 on July 3, 2026, under the Aging Research program (CFDA 93.866) to support Project Grant K99AG092932, a two-year investigation of circadian epigenetic regulation in aging skeletal muscle and the impact of exercise on muscle function. The research examines how age-related decline in circadian clock mechanisms drives reduced homeostatic control and dysfunction in skeletal muscle. The project generates a genome-wide...
- The National Institute on Aging awarded The University of Kentucky Research Foundation $590,826 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop multiscale microgels delivering growth factors to enhance muscle outcomes in sarcopenia. The project tests injectable microgel carriers loaded with glial cell line-derived neurotrophic factor (GDNF) and agrin, both encapsulated in porous silicon nanoparticles. GDNF promotes motor neuron survival and neuromuscular...
The National Institute on Aging awarded the University of Florida $725,528 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on resistance exercise training for older adults with obesity using GLP-1 receptor agonists. The project will evaluate whether progressive, moderate to high-intensity resistance training mitigates muscle loss and strength decline in older adults initiating GLP-1 receptor agonist therapy for obesity treatment. The research addresses a clinical gap: while GLP-1 receptor agonists produce substantial weight loss, they pose unique risks to older adults through rapid muscle mass loss, which increases risk of strength loss, disability, mobility impairment, and falls. The study will assess whether resistance training improves physical function and quality of life measures beyond conventional health education alone, and whether it reduces rebound weight gain commonly experienced after GLP-1 discontinuation. Performance of work occurs in Florida. The project period runs from September 1, 2026, through May 31, 2031. The University of Florida Division of Sponsored Research administers the award as the recipient institution.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $725.5k | 8/31/26 |