Project Grant R21AG095587
- The National Institute on Aging, within the Department of Health and Human Services, awarded $434,856 to the University of Nebraska Board of Regents on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of microRNAs in sarcopenia through a novel muscle-specific mouse model. The recipient will test the hypothesis that microRNA dysregulation contributes to age-related muscle loss by pursuing two specific aims: blocking microRNA-mediated gene repression to...
- The National Institute on Aging awarded The University of Kentucky Research Foundation $616,000 on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop computational and experimental methods for detecting RNA modifications in aging muscle tissue. The project combines nanopore sequencing technology and artificial intelligence to map chemical modifications of RNA molecules—particularly 5-methylcytosine (m5c)—and determine how modification patterns differ between fast- and...
- The National Institute on Aging awarded New York University $466,125 under the Aging Research program (CFDA 93.866) on January 15, 2026, to develop innovative magnetic resonance imaging analysis tools for identifying microstructural biomarkers of skeletal muscle health across the lifespan. The project, titled "(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan," addresses sarcopenia—a leading cause of disability and mortality in aging populations—by creating...
- The National Institute on Aging awarded Wake Forest University Health Sciences $1.31 million on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the synergistic effects of unacylated ghrelin and endurance exercise on sarcopenia and mobility loss in older adults. The research combines unacylated ghrelin (UNAG) administration with endurance exercise training to enhance mitochondrial bioenergetics and preserve neuromuscular junction integrity in aging mice....
- The National Institute on Aging awarded The University of Kentucky Research Foundation $838,582 on February 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a longitudinal human study and translational murine model examining physical function recovery in older adults surviving critical illness. The research will identify clinical and cellular factors that drive disparate recovery trajectories in intensive care unit survivors, with focus on why some older patients return to...
- The National Institute on Aging awarded The University of Kentucky Research Foundation $666,504 on February 1, 2026, under the Aging Research program (CFDA 93.866) to evaluate noninvasive magnetic resonance imaging biomarkers for knee osteoarthritis in older adults. The project develops and validates T1 Rho MRI and diffusion tensor imaging methods to assess muscle quality, fiber size, and fibrosis in the quadriceps of patients with knee osteoarthritis. The recipient will correlate noninvasive...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Johns Hopkins University $427,625 for Project Grant R21AG102518 on September 1, 2026, under the Aging Research program (CFDA 93.866). The recipient will develop a human three-dimensional neuromuscular microphysiological system to model skeletal muscle aging ex vivo. The platform integrates primary human muscle stem cells from young (20–30 years) and aged (60–75 years) donors, induced pluripotent...
- The National Institute on Aging awarded the University of Florida $540,345 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research into a metabolic sensor-driven metabolite repair system that maintains muscle stem cell homeostasis. The research addresses loss of skeletal muscle stem cell function as a central driver of impaired regeneration, progressive muscle wasting, and frailty in aging, muscular dystrophies, and metabolic diseases. The project investigates...
- The National Institute on Aging awarded Panorama Research Incorporated $354,000 on September 20, 2025, under the Aging Research program (CFDA 93.866) to develop a novel therapy for sarcopenia based on the adipokine Isthmin 1 (ISM1). Panorama will generate a panel of longer-lived versions of ISM1 to overcome its current short half-life of minutes, which limits clinical application. The work includes ranking ISM1 variants by activity in vitro and conducting proof-of-concept studies in a rodent...
The National Institute on Aging awarded The University of Kentucky Research Foundation $590,826 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop multiscale microgels delivering growth factors to enhance muscle outcomes in sarcopenia. The project tests injectable microgel carriers loaded with glial cell line-derived neurotrophic factor (GDNF) and agrin, both encapsulated in porous silicon nanoparticles. GDNF promotes motor neuron survival and neuromuscular junction formation, while agrin supports acetylcholine receptor aggregation and neuromuscular junction maintenance. The microgels are designed to sustain protein activity and extend biologic release time at injection sites. Research activities include verification of retained protein activity through neuronal and myocyte in vitro assays and injection studies in muscle tissue. The work addresses sarcopenia—loss of muscle mass and strength affecting over 30 percent of individuals aged 60 and older—for which no therapeutic treatment currently exists beyond resistance training regimens. Performance occurs in Lexington, Kentucky, with a period of performance from September 1, 2026, through August 31, 2029. The assistance type is a Project Grant, structured as a three-year exploratory or developmental award under the National Institute on Aging's biomedical research portfolio supporting aging-related investigations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $590.8k | 8/26/26 |