Project Grant R01AG094130
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging awarded the University of Florida $725,528 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on resistance exercise training for older adults with obesity using GLP-1 receptor agonists. The project will evaluate whether progressive, moderate to high-intensity resistance training mitigates muscle loss and strength decline in older adults initiating GLP-1 receptor agonist therapy for obesity treatment. The research addresses...
- The National Institute on Aging awarded Wake Forest University Health Sciences $1.31 million on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the synergistic effects of unacylated ghrelin and endurance exercise on sarcopenia and mobility loss in older adults. The research combines unacylated ghrelin (UNAG) administration with endurance exercise training to enhance mitochondrial bioenergetics and preserve neuromuscular junction integrity in aging mice....
- The National Institute on Aging, within the Department of Health and Human Services, awarded $434,856 to the University of Nebraska Board of Regents on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of microRNAs in sarcopenia through a novel muscle-specific mouse model. The recipient will test the hypothesis that microRNA dysregulation contributes to age-related muscle loss by pursuing two specific aims: blocking microRNA-mediated gene repression to...
- The National Institute on Aging awarded Arizona State University $436,228 on June 1, 2026, under the Aging Research program (CFDA 93.866) to evaluate the impact of glucagon-like peptide-1 receptor agonists on sarcopenia in older adults. The research project will measure muscle mass and the mechanisms regulating muscle mass—including muscle protein synthesis and breakdown—using stable isotope tracer methodologies in older patients before and six months after GLP-1 RA treatment. The study will...
- The National Institute on Aging awarded The Trustees of The University of Pennsylvania $446,875 on January 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of genetic variants and aging on eicosanoid metabolism in adipose tissue. The research leverages human-derived induced pluripotent stem cells (iPSCs) differentiated into white adipocyte-like cells to examine how the PNPLA3-I148M genetic variant and aging jointly influence polyunsaturated fatty acid (PUFA)...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Johns Hopkins University $427,625 for Project Grant R21AG102518 on September 1, 2026, under the Aging Research program (CFDA 93.866). The recipient will develop a human three-dimensional neuromuscular microphysiological system to model skeletal muscle aging ex vivo. The platform integrates primary human muscle stem cells from young (20–30 years) and aged (60–75 years) donors, induced pluripotent...
- The National Institute on Aging awarded The Washington University $427,625 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate intramuscular adipose tissue quality and its relationship to muscle weakness in aging. The research addresses the mechanism by which ectopic adipose tissue accumulates within muscle boundaries during aging, impairing muscle contraction through secreted signals. The project tests the hypothesis that intramuscular adipose tissue quality...
- The National Institute on Aging awarded The Trustees of the University of Pennsylvania $723,105 on May 15, 2026, under the Aging Research program (CFDA 93.866) to investigate activin A signaling pathways in bone repair mechanisms. The work targets delayed and nonunion fractures, which occur in 5–10% of fractures and pose substantial morbidity and quality-of-life impacts, particularly in aging populations where geriatric fractures are rising in prevalence. The recipient will conduct research on...
- The National Institute on Aging awarded Panorama Research Incorporated $354,000 on September 20, 2025, under the Aging Research program (CFDA 93.866) to develop a novel therapy for sarcopenia based on the adipokine Isthmin 1 (ISM1). Panorama will generate a panel of longer-lived versions of ISM1 to overcome its current short half-life of minutes, which limits clinical application. The work includes ranking ISM1 variants by activity in vitro and conducting proof-of-concept studies in a rodent...
The National Institute on Aging, a component of the Department of Health and Human Services, awarded The Trustees of the University of Pennsylvania $644,239 on August 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of activin type II receptor signaling in muscle physiology, weight loss, and aging. The recipient will conduct research examining muscle loss associated with GLP-1 and GIP receptor agonist treatment, particularly in aged populations where even modest loss of muscle mass and strength impairs functional capacity and metabolic health. The project focuses on how blockade of activin type II receptors preserves or increases skeletal muscle mass while reducing adipose tissue, with the goal of optimizing weight loss quality by maximizing fat loss while protecting lean muscle—a potential mechanism to prevent rapid weight regain after cessation of anti-obesity medications. The research involves both preclinical studies in aged animals and analysis of receptor signaling pathways. The award is a project grant with a period of performance from August 1, 2026, through April 30, 2031. Work is performed at the University of Pennsylvania in Philadelphia, Pennsylvania.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $644.2k | 7/24/26 |