Project Grant K99AG092932
- Federal Grant Award Summary The Buck Institute for Research on Aging received a $533,500 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded July 15, 2026, with completion targeted for June 30, 2028. This award supports research investigating the role of autonomic nervous system (ANS) innervation in muscle stem cell (MuSC) aging and its relationship to sarcopenia—age-related loss of skeletal muscle mass and function affecting 10-22% of...
- Federal Project Grant Award Summary The National Institute on Aging awarded a $698,690 Project Grant to the University of Wisconsin–Madison (effective February 1, 2026, through January 31, 2031) under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms of fiber type-specific skeletal muscle dysfunction with aging. The research addresses a significant health care problem: age-related loss of muscle mass and power-generating capacity (sarcopenia and dynapenia) that...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- Federal Project Grant Award Summary The University of Florida's Division of Sponsored Research received a $126,640 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective September 1, 2025, through May 31, 2030. This research initiative applies machine learning approaches to develop a robust, standardized measure of allostatic load (AL)—a physiological indicator of cumulative "wear and tear" that serves as a pre-clinical marker for chronic...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $427,625 to The Washington University Office of Sponsored Research Services, effective February 15, 2026, through January 31, 2028, under the Aging Research program (CFDA 93.866). This research initiative addresses intramuscular adipose tissue (IMAT) quality in aging populations through a dual-track investigative approach combining human clinical studies and mouse model research. The project delivers...
- Federal Project Grant Summary Wake Forest University Health Sciences received a $599,623 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 1, 2026, through January 31, 2031. The grant funds research investigating the synergistic effects of unacylated ghrelin (UNAG) combined with endurance exercise (EE) on sarcopenia and mobility loss in aging populations. The research project will examine how UNAG+EE enhances mitochondrial...
- Federal Grant Award Summary The University of Florida, Division of Sponsored Research, received a $383,750 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective August 15, 2025, through July 31, 2027. This research project focuses on characterizing age-related changes to the senescence-associated secretory phenotype (SASP) of thyroid tissue in papillary thyroid carcinoma (PTC). The deliverables include scientific research aimed...
- Federal Grant Award Summary Auburn University received a $166,152 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective March 1, 2026, through February 28, 2029. The award supports biomedical research investigating the role of microRNA-1 (miR-1) in regulating pyruvate metabolism and skeletal muscle metabolic dysfunction in patients with peripheral artery disease (PAD). The research employs state-of-the-art molecular techniques...
- Federal Project Grant Award Summary The University of Kentucky Research Foundation received a $616,000 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with completion targeted for January 31, 2029. The project delivers computational and experimental methods to map and characterize ribonucleic acid (RNA) modifications in aging muscle tissue, with particular focus on detecting 5-methylcytosine modifications using...
- Summary The University of Arkansas, Fayetteville is conducting fundamental biomedical research on skeletal muscle aging and rejuvenation under a $141,890 Project Grant (R01) awarded by the National Institute on Aging through its Aging Research program (CFDA 93.866). The project, spanning from June 1, 2025 through July 31, 2030, investigates the role of the MYC transcription factor in mediating muscle functional, metabolic, cellular, and molecular plasticity across the lifespan. Researchers...
The University of Florida Division of Sponsored Research received a $103,969 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective July 3, 2026, with a completion date of June 30, 2028. The award supports research investigating circadian epigenetic regulation of aging skeletal muscle and the impact of exercise on muscle maintenance. The research will generate comprehensive genome-wide, circadian epigenetic and transcriptomic maps of skeletal muscle tissue by conducting molecular assays including RNA-sequencing, assays for transposase-accessible chromatin, and chromatin immunoprecipitation with sequencing on gastrocnemius muscle tissue samples collected from male and female mice at multiple age intervals (6, 18, and 28 months). The primary deliverable is an integrated bioinformatic analysis identifying how age-related decline in circadian oscillations within the skeletal muscle epigenome and transcriptome alters homeostatic control and muscle function, with particular attention to sex-specific differences and the potential of exercise training to modify these age-related changes. This research addresses a critical public health challenge, as age-related skeletal muscle loss significantly impacts quality of life, fall risk, and mortality in aging populations, with global economic implications estimated at $38 trillion annually for a one-year extension in human health span.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $104.0k | 7/7/26 |