Project Grant R21AG098538
- Federal Grant Award Summary Arizona State University received a $675,329 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective May 1, 2026, through February 28, 2031. The award supports research characterizing cellular pathology and biomarkers in an innovative Alzheimer's disease and related dementias (ADRD) model utilizing gene-delivered tauopathy in aged macaque monkeys. The project involves intracortical injections of adeno-associated...
- Federal Project Grant Award Summary Panorama Research Incorporated received a $354,000 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on September 20, 2025, with an ultimate completion date of September 19, 2026. The grant funds the development of a novel therapeutic approach to address sarcopenia—the age-related loss of skeletal muscle mass, quality, and strength—which affects a significant portion of the elderly population, particularly those...
- Federal Project Grant Award Summary The University of Arizona received a $1,279,425 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective August 1, 2025, through May 31, 2030. This award funds research investigating the mechanisms of transactive response DNA binding protein of 43 kDa (TDP-43) liquid-liquid phase separation (LLPS) and its interaction with mitochondrial dysfunction in neurodegeneration. The research addresses a critical...
- Federal Grant Award Summary Arizona State University received a $659,376 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective September 15, 2025, through August 31, 2030. The award funds research to evaluate tai chi and qigong (TCQ)—low-intensity meditative movement practices—as interventions to improve cardiometabolic health in mobility-impaired mid-life women (ages 35-64). The research addresses a significant health equity gap, as women with...
- Federal Project Grant Award Summary San Jose State University Research Foundation received a $183,125 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025 through July 31, 2029. The award funds fundamental biomedical research investigating the mechanisms by which diet regulates muscle stem cell (MUSC) activation and proliferation in Drosophila models. The research...
- Federal Project Grant Summary Rowan University received a $530,469 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective August 15, 2025, through July 31, 2028. The grant supports biomedical research investigating the role of orosomucoid1 in skeletal muscle aging and sarcopenia—age-related muscle loss and functional decline. The research focuses on determining whether orosomucoid1 is necessary for improvements in muscle...
- Federal Grant Award Summary The National Institute on Aging awarded The Washington University a Project Grant totaling $427,625.00 under the Aging Research program (CFDA 93.866) for the period of February 15, 2026, through January 31, 2028. The award funds research investigating intramuscular adipose tissue (IMAT) quality in aging and its relationship to muscle weakness and physical dysfunction in older adults. The research will deliver scientific findings through two parallel research aims: (1)...
- Federal Grant Award Summary The University of Arizona received a $3.03 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on September 30, 2025, with a completion date of September 29, 2029. Led by Principal Investigator Dr. Grilli, this research initiative focuses on developing and validating novel semantic memory assessment measures to detect early Alzheimer's disease (AD) pathology in cognitively unimpaired and mildly...
- Federal Grant Award Summary The University of Arizona received a $1.39 million Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2026, through May 31, 2030. The award supports fundamental biomedical research to identify and modulate mechanistic cellular pathways governing quiescence deepening and transition to senescence—two distinct cellular dormancy states critical...
- Federal Grant Award Summary Arizona State University received a $413,655 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), awarded August 1, 2025, with completion targeted for May 31, 2030. The research project develops biomaterials with temporal control of proteins via genetic fusion with coiled coil peptides to enhance bone repair. The research addresses...
Arizona State University received a $436,228 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective June 1, 2026 through May 31, 2028. The project will investigate the impact of glucagon-like peptide-1 receptor agonist (GLP-1 RA) pharmacotherapy on skeletal muscle health in older adults, addressing a critical knowledge gap regarding potential muscle loss associated with these increasingly prescribed medications. The research will generate foundational scientific data through comprehensive muscle health assessments conducted before treatment initiation and six months after GLP-1 RA therapy begins. The primary deliverables include quantitative measurements of muscle mass changes, analysis of muscle protein synthesis and breakdown mechanisms using stable isotope tracer methodologies, characterization of muscle fiber type distribution through isolated single fiber analysis, assessment of mitochondrial function via respiration assays, and evaluation of overall muscle quality based on strength measurements adjusted for muscle mass. These technical analyses will provide empirical evidence regarding whether GLP-1 RA therapy affects muscle quantity and quality in the older adult population, thereby informing clinical decision-making and filling a significant evidence gap in geriatric pharmacotherapy research. The study is being conducted at Arizona State University's facility in Tempe, Arizona, under the auspices of Arizona Board of Regents as the parent organization.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $436.2k | 5/21/26 |