Project Grant R01AG090295
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $682,281 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell-based three-dimensional brain tissue microsphere model that recapitulates granulin deficiency phenotypes and associated pathology in neurodegenerative diseases including frontotemporal dementia and neuronal ceroid lipofuscinosis. The model...
- The National Institute on Aging awarded The Leland Stanford Junior University $423,500 on April 1, 2026, under the Aging Research program (CFDA 93.866) to investigate dynamic brain circuit mechanisms associated with apathy and disinhibition in individuals with Alzheimer's disease and related dementias. The project addresses neuropsychiatric symptoms that affect nearly 80 percent of individuals with dementia, particularly apathy and disinhibition linked to deficits in motivation and cognitive...
- The National Institute on Aging awarded The Leland Stanford Junior University $630,031 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop an artificial intelligence-driven metabolic clock for distinguishing healthy aging from Alzheimer's disease and Alzheimer's disease-related dementias. The project uses large-scale untargeted metabolomics to identify metabolic deviations associated with cognitive decline in aging and dementia. The research tests the hypothesis...
- The National Institute on Aging awarded The Leland Stanford Junior University $125,766 on July 1, 2026, under the Aging Research program (CFDA 93.866) to identify molecular mediators linking cardiometabolic risk factors to Alzheimer's disease. The research identifies plasma protein and metabolite mediators of cardiometabolic pathways that contribute to Alzheimer's disease risk using large-scale omics data from the UK Biobank and Million Veteran Program. The project comprises three specific aims:...
- The National Institute on Aging awarded The Leland Stanford Junior University $251,532 on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate genetic and proteomic pathways linking Alzheimer's disease to white matter hyperintensities in older adults. The research examines how Alzheimer's disease genetic liability drives white matter hyperintensity burden through circulating protein mediators, with particular focus on African American older adults who carry higher vascular...
- The National Institute on Aging awarded The Leland Stanford Junior University $646,340 on June 15, 2026, under the Aging Research program (CFDA 93.866) to construct and analyze a novel individual-level database linking health trajectories of older adults to the physical, mental, and economic well-being of their family members across multiple generations, covering 1999 to 2024. The recipient will leverage U.S. Census Bureau infrastructure for linking administrative data to examine...
- The National Institute on Aging awarded Drexel University $420,554 under Aging Research (CFDA 93.866) on September 1, 2026, to establish an integrated system for studying senescence and aging in the central nervous system. The award funds two research aims: characterization of the molecular and functional consequences of senescence in astrocyte and neuronal cultures, and evaluation of senescence impact in a multicellular context using hiPSC-derived vascularized cortical organoids. Single-cell...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $1,468,868 on January 15, 2026, under the Aging Research program (CFDA 93.866, Program Grant R01AG097491) to investigate how the brain regulates organismal aging as a neural pacemaker controlling the tempo of aging across multiple organ systems. The research combines high-throughput longitudinal studies in killifish—a vertebrate model with a naturally compressed...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $122,526 on May 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Project Grant K99NS149164). Stanford will use the funding to delineate Alzheimer's disease initiation and propagation using novel adult human brain organoids. The work employs...
- The National Institute on Aging awarded The Leland Stanford Junior University $4.891 million on August 15, 2026, under the Aging Research program (CFDA 93.866) to establish the Stanford University Artificial Intelligence and Technology Collaboratory (SU-AITC) Center for Precision Health & Interventions in Aging and AD/ADRD. The award funds the development and deployment of artificial intelligence algorithms, scalable digital biomarkers, and cost-effective digital interventions to translate...
The National Institute on Aging awarded The Leland Stanford Junior University $667,539 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research on mechanisms of brain repair during aging, with the objective of preventing Alzheimer's disease and Alzheimer's disease-related dementia. The research characterizes neural stem cells (NSCs) during injury and aging to identify interventions that boost repair in aging brains. NSCs reside in specific brain regions including the subventricular zone and generate new neurons, astrocytes, and oligodendrocytes that migrate to injury sites to contribute to repair. The project focuses on understanding age-dependent changes in cell adhesion and migration pathways; preliminary findings show old NSCs are more adhesive and less migratory than young counterparts, defects that may drive age-dependent decline in brain injury repair capacity. The work targets cerebrovascular injuries, including ischemic injury, which accentuate dementia and Alzheimer's disease progression. Performance of work takes place in Palo Alto, California. The period of performance runs from September 1, 2026, through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $667.5k | 8/25/26 |