Project Grant R21AG093006
- Federal Grant Award Summary The National Institute on Aging awarded The Leland Stanford Junior University a $165,888 Project Grant on August 15, 2025, under the Aging Research program (CFDA 93.866) to conduct research on neuroimaging and genetics of the glymphatic system in Alzheimer's disease through May 31, 2030. The research will deliver novel, non-invasive diagnostic markers characterizing the brain's glymphatic system—its waste clearance mechanism—by combining three complementary...
- Federal Project Grant Award Summary The National Institute on Aging awarded $620,020 to The Leland Stanford Junior University under the Aging Research program (CFDA 93.866) to conduct a comprehensive research project examining the effects of health shocks on older adults and their families. The project, initiated September 30, 2025 and concluding August 31, 2027, will construct and analyze a novel individual-level database linking health trajectories of older adults to the physical, mental,...
- Federal Grant Award Summary The National Institute on Aging awarded a $762,636 Project Grant to The Leland Stanford Junior University on May 15, 2025, under the Aging Research program (CFDA 93.866) to develop interpretable machine learning (ML) methods for analyzing Alzheimer's disease genetics. The primary deliverable is the development of rigorous feature selection techniques in ML methodologies paired with causal inference approaches to identify causal genetic variants associated with...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Leland Stanford Junior University a Project Grant of $1,468,868 on January 15, 2026, under the Aging Research program (CFDA 93.866) to support a multi-investigator research initiative examining the brain's role as a neural pacemaker in regulating organismal aging. The research leverages the killifish model organism—a vertebrate with a naturally compressed lifespan of approximately six months—to conduct high-throughput,...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded University of California, San Diego $3,138,871 under the Aging Research program (CFDA 93.866) to conduct a comprehensive four-year research project examining human neuropeptide transmitter systems in Alzheimer's disease (AD) pathogenesis. The project, initiated September 15, 2025 and concluding August 31, 2029, will deliver scientific research services focused on defining the complete repertoire of human brain...
- Federal Project Grant Award Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded The Leland Stanford Junior University a project grant of $1,526,066 to conduct biomedical research on shared mechanisms of tau toxicity across neurodegenerative diseases. The award, effective June 1, 2025, through April 30, 2030, supports comprehensive scientific investigation designed to advance understanding of how tau protein hyperphosphorylation and aggregation...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Leland Stanford Junior University a $770,000 Project Grant (R03) on August 15, 2025, under the Aging Research program (CFDA 93.866). The award supports basic science research investigating how aldehyde dehydrogenase 2 (ALDH2) regulates oxidative stress during anesthesia, with particular focus on aging-related cognitive recovery delays and implications for Alzheimer's disease. Through a two-year project period...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $3.22 million Project Grant under the Aging Research program (CFDA 93.866) to the University of California, Irvine on September 15, 2025, for research investigating the role of the retrosplenial cortex (RSC) in Alzheimer's disease (AD) pathogenesis. The project, which extends through August 31, 2029, will deliver scientific research products including characterization of neuronal hyperexcitability mechanisms in...
- Federal Grant Award Summary The National Institute on Aging awarded a $1,170,020 Project Grant to The Leland Stanford Junior University effective June 1, 2025, through February 28, 2030, under the Aging Research program (CFDA 93.866). The EMERGED (Enhancing the Implementation, Effectiveness, and Reach of Geriatric Emergency Departments for Older Adults with Dementia) project will deliver comprehensive research and implementation guidance designed to improve emergency department care for older...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $1,450,964 Project Grant to The Regents of the University of California, Berkeley, under the Aging Research program (CFDA 93.866) to develop novel statistical methodologies for understanding heterogeneous causal pathophysiology of Alzheimer's disease (AD). The award, issued May 15, 2025, with completion targeted for February 28, 2030, addresses a critical gap in understanding how and when amyloid-beta-lowering...
The National Institute on Aging awarded a $423,500 Project Grant to The Leland Stanford Junior University effective April 1, 2026, through March 31, 2028, under the Aging Research program (CFDA 93.866). This research initiative, "Uncovering Dynamic Brain Circuit Mechanisms Associated with Apathy and Disinhibition in Alzheimer's Dementia," investigates the neural mechanisms underlying neuropsychiatric symptoms in Alzheimer's disease and related dementias (ADRD). The research will employ novel computational modeling to characterize brain circuit dynamics within motivation and cognitive control systems, examining how Alzheimer's pathology contributes to apathy and disinhibition symptoms affecting approximately 80% of individuals with dementia. The project leverages the Research Domain Criteria (RDoC) framework to identify latent brain states and their temporal-spatial characteristics, ultimately advancing mechanistic understanding of how dysfunction in these systems contributes to neuropsychiatric manifestations in older adults. The deliverables from this two-year project will include scientific findings on the relationships between Alzheimer's pathology, aberrant neural dynamics, and neuropsychiatric symptoms in ADRD populations, with results disseminated through peer-reviewed publications and research presentations. This work addresses a critical gap in understanding how aging and disease pathology affect brain circuit dynamics and supports the National Institute on Aging's mission to identify effective approaches for preventing and treating Alzheimer's disease and related dementias through biomedical research.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.5k | 3/18/26 |