Project Grant P30AG102665
- The National Institute on Aging awarded The Leland Stanford Junior University $630,031 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop an artificial intelligence-driven metabolic clock for distinguishing healthy aging from Alzheimer's disease and Alzheimer's disease-related dementias. The project uses large-scale untargeted metabolomics to identify metabolic deviations associated with cognitive decline in aging and dementia. The research tests the hypothesis...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $682,281 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell-based three-dimensional brain tissue microsphere model that recapitulates granulin deficiency phenotypes and associated pathology in neurodegenerative diseases including frontotemporal dementia and neuronal ceroid lipofuscinosis. The model...
- The National Institute on Aging awarded The Leland Stanford Junior University $667,539 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research on mechanisms of brain repair during aging, with the objective of preventing Alzheimer's disease and Alzheimer's disease-related dementia. The research characterizes neural stem cells (NSCs) during injury and aging to identify interventions that boost repair in aging brains. NSCs reside in specific brain regions...
- The National Institute on Aging awarded The Leland Stanford Junior University $646,340 on June 15, 2026, under the Aging Research program (CFDA 93.866) to construct and analyze a novel individual-level database linking health trajectories of older adults to the physical, mental, and economic well-being of their family members across multiple generations, covering 1999 to 2024. The recipient will leverage U.S. Census Bureau infrastructure for linking administrative data to examine...
- The National Institute on Aging awarded The Leland Stanford Junior University $125,766 on July 1, 2026, under the Aging Research program (CFDA 93.866) to identify molecular mediators linking cardiometabolic risk factors to Alzheimer's disease. The research identifies plasma protein and metabolite mediators of cardiometabolic pathways that contribute to Alzheimer's disease risk using large-scale omics data from the UK Biobank and Million Veteran Program. The project comprises three specific aims:...
- The National Institute on Aging awarded The Leland Stanford Junior University $251,532 on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate genetic and proteomic pathways linking Alzheimer's disease to white matter hyperintensities in older adults. The research examines how Alzheimer's disease genetic liability drives white matter hyperintensity burden through circulating protein mediators, with particular focus on African American older adults who carry higher vascular...
- The National Institute on Aging awarded the University of California, Berkeley $549,260 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop advanced large language model-based AI tools that enhance precision in predicting Alzheimer's disease pathology and cognitive outcomes. The research addresses critical gaps in precision medicine for Alzheimer's disease, particularly the need to capture patient heterogeneity, accurately identify treatment candidates for...
- The National Institute on Aging awarded The Leland Stanford Junior University $1.24 million on September 30, 2025, under the Aging Research program (CFDA 93.866) to construct and analyze a novel individual-level database linking health trajectories of older adults to the physical, mental, and economic well-being of their family members across multiple generations, covering 1999 to 2024. The project leverages Census Bureau infrastructure for linking U.S. survey and administrative data to...
- The National Institute on Aging awarded Duke University $4.899 million on August 15, 2026, under the Aging Research program (CFDA 93.866) to establish the Duke Artificial Intelligence and Technology Collaboratory for Aging: Governance and Evaluation (DUKE AITC-AIGE), a national initiative bridging the implementation gap between artificial intelligence research and its application in care for older adults and individuals with Alzheimer's disease and related dementias. The collaboratory operates...
- The National Institute on Aging awarded The Leland Stanford Junior University $423,500 on April 1, 2026, under the Aging Research program (CFDA 93.866) to investigate dynamic brain circuit mechanisms associated with apathy and disinhibition in individuals with Alzheimer's disease and related dementias. The project addresses neuropsychiatric symptoms that affect nearly 80 percent of individuals with dementia, particularly apathy and disinhibition linked to deficits in motivation and cognitive...
The National Institute on Aging awarded The Leland Stanford Junior University $4.891 million on August 15, 2026, under the Aging Research program (CFDA 93.866) to establish the Stanford University Artificial Intelligence and Technology Collaboratory (SU-AITC) Center for Precision Health & Interventions in Aging and AD/ADRD. The award funds the development and deployment of artificial intelligence algorithms, scalable digital biomarkers, and cost-effective digital interventions to translate research prototypes into validated technologies for clinical adoption in Alzheimer's disease and related dementias prevention and treatment. The SU-AITC will operate as a national hub addressing three major aims: providing research leadership in AD/ADRD and AI-assisted precision intervention research; supporting translational research innovation and multidisciplinary collaborations that advance clinical and social impact; and establishing resources and infrastructure for the field. Work will be performed in Palo Alto, California with a period of performance from August 15, 2026 through July 31, 2031. The award supports research designed to advance systematic advances in intervention design, implementation, dissemination, analytics, and deployment science to address the profound heterogeneity of populations at risk for or living with Alzheimer's disease and related dementias, leveraging Stanford's strengths at the intersection of AI, neuroscience, geriatrics, health service research, and innovation infrastructure.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $4.9m | 7/31/26 |