Project Grant K01AG101395
- Federal Grant Award Summary Award Details: The National Institute on Aging (NIA) awarded The Leland Stanford Junior University a $331,776 Project Grant on August 15, 2025, under the Aging Research program (CFDA 93.866). The project, titled "Neuroimaging and Genetics of the Glymphatic System in Alzheimer's Disease," extends through May 31, 2030, and is being conducted in Palo Alto, California. Research Deliverables: The project will develop and validate novel, non-invasive...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant totaling $125,766 to The Leland Stanford Junior University beginning July 1, 2026, through April 30, 2030, under the Aging Research program (CFDA 93.866). The project, "Discerning the Molecular Mediators Between Cardiometabolic Risk Factors and Alzheimer's Disease," will identify molecular pathways linking cardiometabolic traits to Alzheimer's disease (AD) risk. Research outputs include...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Leland Stanford Junior University a $770,000 Project Grant under the Aging Research program (CFDA 93.866) to conduct basic science research addressing postoperative delirium in geriatric populations. Awarded August 15, 2025, with completion scheduled for July 31, 2027, the project will investigate the central role of aldehyde dehydrogenase 2 (ALDH2) in regulating oxidative stress during anesthesia, with...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Leland Stanford Junior University a Project Grant of $149,190 under the Aging Research program (CFDA 93.866) on July 29, 2026, with a completion date of February 1, 2028. This grant supports the development and assessment of novel positron emission tomography (PET) radiotracers targeting G protein-coupled receptor 84 (GPR84) for imaging innate immune activation in Alzheimer's disease. The project addresses a critical...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Stanford University a $646,340 Project Grant on June 15, 2026, under the Aging Research program (CFDA 93.866) to construct and analyze a novel individual-level database linking health trajectories of older adults to the physical, mental, and economic well-being of their family members. The primary deliverable is a comprehensive dataset covering twenty-five years (1999–2024) that leverages U.S. Census Bureau...
- Federal Grant Award Summary The National Institute on Aging awarded the University of Pittsburgh a $2.0 million Project Grant (CFDA 93.866: Aging Research) effective September 15, 2025, through August 31, 2029, to investigate white matter injury in Alzheimer's disease (AD). The research will characterize risk factors and consequences of white matter injury in brain regions affected by AD pathology using a novel measurement method called Unhealthy White Matter Connectivity (UWMC). The study...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $1,459,072 on August 1, 2025, under the Aging Research program (CFDA 93.866) to conduct research on Alzheimer's Disease (AD)-related neurological dysfunction. The research will deliver scientific knowledge and methodological innovations focused on understanding how inhibitory interneurons—specifically parvalbumin (PVALB) and somatostatin (SST) cell types—contribute...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Leland Stanford Junior University a Project Grant of $122,526 on May 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research initiative, titled "Delineation of Alzheimer's Disease Initiation and Propagation Using Novel Adult Human Brain Organoids," is scheduled for completion by April 30, 2028,...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $1.24M Project Grant to The Leland Stanford Junior University to develop and analyze a novel individual-level database linking health trajectories of older adults to the physical, mental, and economic well-being of their family members across multiple generations from 1999 to 2024. The grant, obligated on September 30, 2025, under the Aging Research program (CFDA 93.866), addresses a significant gap in U.S....
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $643,139 Project Grant to the University of California, Los Angeles, effective September 30, 2025, through August 31, 2027, under the Aging Research program (CFDA 93.866). The TARDIS-AD Project (Targeted Multi-Factorial Approaches to Reducing Disparities in Alzheimer's Disease) will deliver research services focused on identifying personalized intervention strategies to reduce health disparities in Alzheimer's disease...
The National Institute on Aging (NIA) awarded a $125,766 Project Grant to The Leland Stanford Junior University effective July 1, 2026, through April 30, 2031, under the Aging Research program (CFDA 93.866). The research project investigates genetic and proteomic pathways linking Alzheimer's Disease (AD) to white matter hyperintensities (WMH), specifically examining how AD genetic liability drives WMH burden through circulating protein mediators. The study addresses a significant public health gap by exploring how AD pathology contributes to WMH lesions in African American older adults, a population that carries higher vascular risk yet demonstrates lower measured brain amyloid while developing dementia at higher rates than other populations. The project will employ high-dimensional biological data analysis—integrating genetics and plasma proteomic measures with neuroimaging data—combined with advanced epidemiological and biostatistical methods across two major cohorts: the UK Biobank and the Jackson Heart Study. Specifically, researchers will conduct Mendelian randomization analyses to quantify causal associations between AD-related genes and WMH, identify proteomic mediators of AD genetic risk, and develop ancestry-tuned polygenic risk scores intended to markedly improve dementia prediction across diverse populations. This research directly supports NIA's mission to advance understanding of Alzheimer's disease and related dementias and to identify prevention and treatment approaches for age-related conditions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.8k | 6/30/26 |