Project Grant R21AG102492
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging awarded The Salk Institute for Biological Studies $1.359 million on February 15, 2026, under the Aging Research program (CFDA 93.866) to characterize activity-dependent changes to neuronal populations in the spinal dorsal horn during aging and determine functional consequences for sensorimotor behaviors. The research selectively perturbs activity in different classes of cutaneous afferent neurons to identify inputs that support cell survival in adult mice,...
- The National Institutes of Health's National Institute on Aging awarded $256,331.40 under the Aging Research program (CFDA 93.866) to The Trustees of the University of Pennsylvania from February to October 2021. The project aims to develop novel machine learning algorithms and biomedical software to more accurately quantify brain aging and predict the onset of neurodegenerative diseases such as Alzheimer's. Specifically, the funding will support refining predictive models of the...
- The National Institute on Aging awarded The Leland Stanford Junior University $667,539 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research on mechanisms of brain repair during aging, with the objective of preventing Alzheimer's disease and Alzheimer's disease-related dementia. The research characterizes neural stem cells (NSCs) during injury and aging to identify interventions that boost repair in aging brains. NSCs reside in specific brain regions...
- The National Institute on Aging awarded The Scripps Research Institute $645,242 on July 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on chemical modulation of proteostasis to promote longevity and healthy aging. The award funds development of chemical and computational tools to selectively attenuate polysome-mediated translation in vivo, quantify protein conformational changes across the neuronal proteome with age, and assess healthy aging and behavior in...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $1,468,868 on January 15, 2026, under the Aging Research program (CFDA 93.866, Program Grant R01AG097491) to investigate how the brain regulates organismal aging as a neural pacemaker controlling the tempo of aging across multiple organ systems. The research combines high-throughput longitudinal studies in killifish—a vertebrate model with a naturally compressed...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Thomas Jefferson University $429,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to characterize neurodegenerative hallmarks in induced neural stem cells (iNSCs) derived from patient fibroblasts to study dsRNA-mediated inflammation in C9ORF72-associated ALS and frontotemporal dementia. The research employs a novel disease model using age-preserved iNSCs directly...
- The National Institute on Aging awarded $648,930 to the Regents of the University of California, doing business as University of California, Berkeley, on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop human stem cell-based microphysiological systems for aging research. The recipient will create a novel human aging-on-a-chip platform integrating fat and liver tissues derived from human induced pluripotent stem cells (hiPSCs) and microfluidics using serum from young...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
The National Institute on Aging awarded Drexel University $420,554 under Aging Research (CFDA 93.866) on September 1, 2026, to establish an integrated system for studying senescence and aging in the central nervous system. The award funds two research aims: characterization of the molecular and functional consequences of senescence in astrocyte and neuronal cultures, and evaluation of senescence impact in a multicellular context using hiPSC-derived vascularized cortical organoids. Single-cell sequencing data will be integrated with existing single-cell data from aged tissue to establish a novel system examining senescence effects on brain homeostasis and microenvironmental signaling. Performance occurs in Philadelphia, Pennsylvania, with a period of performance from September 1, 2026, through August 31, 2028. This is a Project Grant assistance type, which supports biomedical research directed toward understanding aging processes and diseases affecting older adults.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $420.6k | 8/27/26 |