Project Grant R01AG089247

Award Date 6/1/25
Completion Date 2/28/30
Dollars Obligated $801K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Maryland, USA
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The project aims to use advanced magnetic resonance imaging (MRI) techniques to assess changes in cerebral blood vessels, perivascular spaces, lymphatic vessels, blood-brain barrier integrity, and neuroinflammation in obesity mouse models. The researchers will correlate these MRI measures with pathological and cognitive impairment data to identify potential biomarkers for early diagnosis and evaluation of interventions for obesity-related cognitive decline. The outcomes are expected to provide new insights into the neuropathological mechanisms underlying obesity-linked cognitive impairment, which could facilitate the development of non-invasive diagnostics and treatment targets.

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