The University of Virginia (UVA) was awarded a $218,261 project grant (R21AG085597) by the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate the molecular mechanisms connecting obesity and Alzheimer's disease. The two-year research project aims to: 1) genetically identify the pathways through which obesity activates the protein MOAG-4/SERF2 in neuronal cells, and 2) determine the specific aspects of obesity-induced neurological and motor decline that are mediated by MOAG-4. This exploratory award will lay the groundwork for future studies to ascertain if the identified pathways are conserved in mammalian models. The overarching objective is to delineate the MOAG-4/SERF2 pathway that connects obesity to Alzheimer's disease with sufficient precision to enable targeted therapeutic interventions.
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