Project Grant R00AG071667

Award Date 9/1/24
Completion Date 5/31/27
Dollars Obligated $249K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
East Lansing, MI 48824, USA
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,380,018 to the Regents of the University of Michigan to conduct research on the impact of type 2 diabetes and prediabetes on cognitive decline and Alzheimer's disease risk over the life course. The research team will quantify how cumulative hyperglycemia and diabetes management affect cognitive trajectories and Alzheimer's disease risk, and identify potential mechanisms linking...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $720,621 to the University of Massachusetts Medical School to investigate the role of peripheral insulin resistance and inflammation in Alzheimer's disease (AD) pathogenesis. The key objectives are to: Define age-related changes in metabolism and inflammation in peripheral organs and the brain during AD-relevant neurodegeneration in a mouse model. This includes measuring organ-specific...
This federal Project Grant award for $218,261, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to advance the understanding of the molecular connection between obesity and Alzheimer's disease (AD). The principal investigator (PI) at the University of Virginia (UVA) will conduct a two-year exploratory study to: Genetically identify the molecular pathways through which obesity activates the MOAG-4 protein in neuronal cells of the model...
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $787,390 to Rush University Medical Center to examine the relationship between diet, neuroinflammation, brain oxidative stress, and plasma neurodegenerative biomarkers in a diverse population. The goal is to elucidate the link between diet and Alzheimer's disease/age-related dementias (AD/ADRD). The project will leverage four longitudinal community cohorts to collect new data and...
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This $249,000 project grant, awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to investigate the mechanisms by which midlife obesity and prediabetes contribute to later-life cognitive decline and Alzheimer's disease-related dementias (AD/ADRD). The key objectives are to:

  1. Establish the role of the cGAS/STING inflammatory pathway and the broader inflammatory milieu during the progression from midlife obesity and prediabetes to later-life cognitive impairment.

  2. Determine the specific role of microglial cGAS/STING in high-fat diet-induced cognitive deficits in mid and later life.

  3. Examine how extracellular vesicle-mediated cGAS/STING inflammatory crosstalk in the central nervous system contributes to obesity- and prediabetes-driven cognitive decline during aging.

The study, which will be conducted at Michigan State University from Sep 2024 to May 2027, aims to identify disease-modifying targets and optimal therapeutic windows for early intervention to prevent the development of AD/ADRD.

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