This Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) provides $842,114 to the Icahn School of Medicine at Mount Sinai to systematically investigate the molecular mechanisms of brain senescence in different Alzheimer's disease (AD) subtypes. The goal is to identify novel targets and develop therapeutics for AD. The multi-disciplinary research team will use a comprehensive "senome" profiling pipeline to...
This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
This $254,250 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine will develop a biologically relevant multi-scale model of brain aging using advanced diffusion magnetic resonance imaging (dMRI) techniques. The project aims to create brain charts of quantitative dMRI and mesoscopic MRI (mesoMRI) markers across the lifespan to establish a brain microstructure age framework. In the second phase, the researchers will...
The National Institute on Aging (NIA) awarded a $2,947,959 project grant (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai to study the effects of cardiovascular health on lifespan, brain function, and age-related diseases in humans and great apes. The research aims to evaluate the impact of aging, cardiovascular disease, and neurovascular health on brain structure and function, identify associations between vascular risk factors and cognitive impairment in great...
This $4,950,026 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Icahn School of Medicine at Mount Sinai is investigating potential synergy between HIV infection and amyloid beta, a hallmark of Alzheimer's disease, in promoting memory impairment. Researchers will characterize enhanced HIV neuropathogenesis in familial and late-onset Alzheimer's disease mouse models...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $105,952.00 to support research on the identification and characterization of clonal expansions in aging and aging-related diseases. The project aims to (1) develop tools to identify candidate somatic variants at scale from publicly available data, and (2) apply novel technologies that map genotypes to epigenetic phenotypes in single cells to analyze multiple tissues from aging...
This federal Project Grant award, valued at $205,619 and awarded by the National Institute on Aging under CFDA 93.866 (Aging Research), will support research to map the landscape of the aged human brain in order to develop neurodegenerative disease models. The grant recipient, the University of Washington, will apply explainable artificial intelligence (XAI) methods to human brain data sets to identify molecular drivers of brain aging. The researchers will then manipulate these aging-related...
This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866, the Aging Research program, provides $835,417 in funding to the Icahn School of Medicine at Mount Sinai (ISMMS) to develop novel lipid nanoparticle (LNP) formulations for delivering nucleic acid therapeutics across the blood-brain barrier to treat Alzheimer's disease (AD). The key objectives are to synthesize BBB-crossing lipids, formulate LNP libraries, elucidate trafficking pathways, engineer targeted...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $412,751 to The Trustees of Columbia University in the City of New York to conduct research into understanding protein turnover alterations in physiological brain aging. The key objectives are to: (I) study the stoichiometry of the ribosome and proteasome; (II) measure changes in protein complex composition at the whole proteome level; (III) reveal how protein interaction state...
This three-year project grant from the National Institutes of Health's National Institute on Aging, titled "Aging Research" under the CFDA number 93.866, provides $1,797,870 to Stony Brook University to investigate the mechanisms by which aging impacts the risks of Alzheimer's and related dementias. Specifically, the awardee will test the hypothesis that age and neurodegenerative protein pathology synergize to activate retrotransposons and endogenous retroviruses, mobile genetic...
This $1,394,250 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the Icahn School of Medicine at Mount Sinai to study the molecular mechanisms underlying the heterogeneity of human tissue aging, with a focus on identifying common pathological aging pathways between brain and adipose tissues. The project aims to classify healthy versus pathological aging in these tissues, and to investigate potential molecular mechanisms mediating cross-talk between the brain and adipose tissue that may contribute to age-related neurological and metabolic disorders. Key products will include the identification of common gene regulation patterns in pathological aging across brain and adipose tissue, as well as experimental validation of transcriptomic changes involved in the adipose-brain axis. The research is expected to generate important insights into the mechanisms of pathological aging and how peripheral tissue aging may impact brain health.