This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Trustees of Boston University, doing business as Boston University Medical Campus, provides $2,330,859.00 in funding to study age-related changes in brain network connectivity and their relationship to cognitive decline. The 3-year project aims to use multimodal neuroimaging, single-cell transcriptomics, electrophysiology, and neural tract-tracing in a rhesus monkey model to delineate how...
The National Institute on Aging (NIA) awarded a $689,525 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to New York University (NYU) to investigate the integration of cell-specific microstructure within long-range brain networks in the macaque monkey. The project aims to disentangle cell-type specific signatures of brain microstructure using in vivo MRI techniques and determine how these signatures vary across individuals. This work will contribute to a...
This $6,226,692 project grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support research to examine the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the development of Alzheimer's disease (AD). The primary focus is on investigating how modifications in brain activity, particularly in the locus coeruleus (LC) and hippocampus (HPC) regions, can lead to the key pathological hallmarks of AD....
The National Institute on Aging (NIA) awarded a $137,895 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of California, Berkeley (UC Berkeley) with a project period from December 3, 2024 to July 31, 2027. The grant will fund a study to investigate how brain network connectivity is associated with Alzheimer's disease (AD) risk, longitudinal pathology accumulation, and aging. Specifically, the project will use positron emission tomography (PET)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $466,125 to New York University (NYU) to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The project aims to generate brain charts of quantitative dMRI and mesoscopic MRI (mesoMRI) markers across the lifespan, creating a brain microstructure age framework. This framework will then be used to evaluate the effects of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $416,480 to the University of Washington to map the landscape of the aged human brain and develop neurodegenerative disease models. The award will fund a two-phase research project that aims to: 1) identify molecular drivers of brain aging by applying explainable artificial intelligence (XAI) methods to human brain datasets, and 2) manipulate these aging drivers in human induced pluripotent stem...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research Federal Grant Program (CFDA 93.866) provides $1,394,250 to the Icahn School of Medicine at Mount Sinai to study the molecular mechanisms underlying pathological aging of the human brain and adipose tissue, as well as their inter-organ communication. The project aims to investigate the heterogeneity of human aging and identify the common pathological aging mechanisms shared between the brain (e.g., hippocampus,...
This $412,751 Project Grant, awarded on August 15, 2024 by the National Institute on Aging (CFDA 93.866 - Aging Research), will fund research by The Trustees of Columbia University in the City of New York to study protein turnover alterations in the aging brain. The project aims to: (I) study the stoichiometry of the ribosome and proteasome; (II) measure changes in protein complex composition; (III) reveal how aging affects protein interaction state turnover; and (IV) address the effects of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study to examine how high-resolution diffusion imaging can provide new insights into age-related changes in white matter connectivity and their impact on cognitive function and brain network dynamics. The $300,892 award to Duke University, which runs from October 2024 through April 2027, will support research across three aims: 1) comparing standard and high-resolution diffusion imaging...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $636,342 to Trustees of Boston University's Boston University Medical Campus to conduct multiscale modeling and empirical studies of normal and pathological brain aging. The research aims to elucidate the relationships between myelin dystrophy, synaptic loss, and neuronal hyperexcitability in the dorsolateral prefrontal cortex, and how these changes contribute to age- and Alzheimer's...