Project Grant R01AG086764

Award Date 6/1/24
Completion Date 3/31/29
Dollars Obligated $706K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
New York, NY 10032, USA
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This federal Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research), will fund a comprehensive study on mapping mitochondrial diversity in the aging brain and immune system. The total funding amount is $705,775, with an award date of June 1, 2024 and an ultimate completion date of March 31, 2029.

The key products and services to be delivered under this grant include:

  1. Generating sensitive mitotype profiles for over 1.4 million brain cortical cells (neurons, glia, and other cell types) across 381 older adults to establish cell type-specific mitochondrial recalibrations associated with age, sex, cognitive reserve, and Alzheimer's disease.
  2. Deploying the same mitotyping approach in over 0.9 million circulating immune cells from 175 adults aged 20-80 to establish sex-specific immune mitotypes associated with age, cognitive reserve, and Alzheimer's disease.
  3. Dissecting the effects of genetic and pharmacological perturbations of the mitochondrial oxidative phosphorylation system on mitotype signatures in living human cells over time, and examining how mitochondrial impairments in one cell population influence the mitotypes of other cell populations.
  4. Developing an online platform, MitotypeExplorer 2.0, to make mitotyping approaches accessible to the broader neuroscience and immunology research communities.

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