This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research into the cell autonomous and cell non-autonomous roles of mitochondrial proline catabolism in health and longevity. The $126,042 award to the University of Southern California, effective February 1, 2025 through July 31, 2025, will employ innovative techniques including CRISPR/Cas9 genetic editing, single-cell RNA sequencing, and mitochondrial assessments to comprehensively characterize...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $388,067 to support an interdisciplinary investigation of functional asymmetry and topological restructuring within mitochondrial networks during cellular aging. The primary awardee is Northwestern University, which will partner with the University of California, San Diego on the project. The research aims to mechanistically investigate how mitochondrial positioning and dynamics contribute to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $793,777 to the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco, CA, to study the impact of mitochondrial genome architecture on the accumulation of somatic mitochondrial DNA (mtDNA) mutations over an individual's lifetime. The research aims to understand how mtDNA compaction influences mutation rates and mitochondrial health, with potential...
This Project Grant award from the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, provides $146,922 to the University of Southern California to conduct research aimed at triggering the selective removal of deleterious mitochondrial DNA (mtDNA) mutations from mammalian cells. The goal is to develop treatments to prevent or ameliorate age-related and pediatric diseases associated with mtDNA mutations. The research will utilize genetic and molecular biology tools, combined with...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $399,766 to the University of Kansas Center for Research Inc. from January 1, 2025 to December 31, 2026. The project aims to understand the dynamics between mitochondrial and nuclear genome variation, and how this impacts mitochondrial dysfunction and associated diseases like neuromuscular disorders, cancers, and metabolic diseases. The research will leverage a novel animal model, the threespine...
This Project Grant award, valued at $935,708 and provided by the National Institute on Aging (NIA) under CFDA 93.866 Aging Research, will support research to investigate the spatial and temporal heterogeneity of mitochondria and its relationship to physiological homeostasis throughout the lifespan. The primary awardee, Georgia TECH Research Corp, will utilize advanced in vivo chemical imaging techniques including broadband coherent anti-Stokes Raman scattering (BCARS) and two-photon fluorescence...
The National Institute on Aging (NIA) awarded a $161,922 project grant under the Aging Research (CFDA 93.866) program to The Research Foundation for the State University of New York (RF SUNY) to support research on "Mechanism of Mitochondria-Induced Myokine Activation and Implications for Healthy Aging." The project aims to investigate how mitochondrial protein import stress can induce myokine signaling, and how this process may mediate fat loss and cardiac health improvements during...
This $101,925 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to investigate the role of the propionate metabolism pathway in the aging process. The 2-year project aims to: Continue studying the impact of methylmalonic acid (MMA), a metabolite in the propionate pathway, on cell senescence and aging-associated pulmonary fibrosis. Characterize a novel function of propionyl-CoA (P-CoA), another pathway...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $153,512.00 to the Regents of the University of Minnesota to conduct research on the relationship between lipid metabolism, mitochondrial stress, and cellular senescence. The key objectives are to: 1) use proteomics to characterize mitochondrial protein targets of carbonylation during obesity and aging, and 2) investigate the role of mitochondrial stress and signaling on adipose tissue...
The Scintillon Institute, a non-profit biomedical research organization, received a $529,650 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate NAD(P)H quinone oxidoreductase 1 (NQO1)-mediated bypass of the mitochondrial electron transport chain. The research aims to identify endogenous metabolites interconverted by NQO1 and characterize the bioenergetics of this alternative electron transfer mechanism, with the goal of developing therapeutic...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a comprehensive investigation into the relationship between mitochondrial function and aging-related diseases. The $2,672,656 award to The Johns Hopkins University will leverage genetic variation data, metabolomics, and proteomics to identify novel biomarkers of mitochondrial function and assess their causal associations with all-cause mortality, cardiovascular disease, and frailty. The 4-year project will first identify plasma biomarkers linked to mitochondrial DNA variation, then establish phenotypic associations between these biomarkers and aging-related health outcomes. Utilizing Mendelian randomization techniques, the researchers will aim to discriminate causal from non-causal relationships and characterize the underlying mitochondrial genes and functional variants. The goal is to uncover therapeutic targets for aging-related diseases exacerbated by mitochondrial deficiency.