This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $126,956 to the University of California, San Diego (UCSD) to conduct research on generating new neurons in the aging adult brain. The key objectives are to: Use single cell spatial transcriptomics to define the cellular pathway and molecular mechanisms underlying the conversion of glial cells into functional replacement neurons in the aged mouse brain. This approach was previously...
This federal Project Grant award, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports research into the role of senescent cells in brain aging and Alzheimer's disease and related dementias (ADRD). The $654,238 award, with a start date of September 15, 2024 and an ultimate completion date of June 30, 2026, aims to generate high-resolution spatial omics data from ADRD brains and corresponding mouse models to identify molecular changes in the...
This federal Project Grant award, valued at $131,027.00, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866) to The Leland Stanford Junior University. The award aims to study neuronal proteostasis, the maintenance of protein health, during brain aging and Alzheimer's disease (AD). The key products and services to be delivered under this grant include: Conducting in vivo experiments using a novel bioorthogonal non-canonical amino acid tagging (BONCAT)...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $173,140 to The Regents of the University of California, San Francisco (UCSF) to investigate the role of neural activity in the degeneration of midbrain dopamine neurons associated with Parkinson's disease. The project aims to develop novel mouse models to chronically...
This $3,845,311 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund research at the University of California, San Diego (UCSD) to investigate early determinants of Alzheimer's disease (AD) using patient-derived induced neurons (iNs). The project aims to better understand the mechanisms that cause mild cognitive impairment (MCI) and the progression to AD, integrating multi-omic analysis of MCI patient-specific iNs with polygenic risk scores....
This federal Project Grant award in the amount of $684,451 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders supports a comprehensive research effort to advance understanding and treatment of Parkinson's disease. The project aims to: Identify Parkinson's disease progression subtypes through integrative analysis of longitudinal clinical, transcriptomic, and neuroimaging data...
This Project Grant award of $1,086,563.00 from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research conducted by The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, to define the regulation of lysosome-mediated pathways within and between astrocytes and neurons in response to proteotoxic stress from alpha-synuclein aggregation. The research aims to elucidate cell-type-specific...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $414,521 to The Regents of the University of California, doing business as the University of California, Berkeley, for a 2-year research project. The goal is to develop cultured elephant seal cells as a model system to identify new mechanisms that suppress oxidative stress and ferroptosis, a form of regulated cell death. The project aims to use CRISPR-Cas9 genetic editing tools and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,841,367 to The Regents of the University of California, San Francisco to conduct research on understanding the role of the TBK1 protein kinase in regulating selective autophagy pathways in neurons. The key objectives are to: 1) Identify novel TBK1 protein substrates and characterize the effects of TBK1 loss on neural regeneration using human stem cell-derived neuron models; 2) Define the...
This $205,619 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to map the landscape of the aged human brain and model neurodegenerative diseases like Alzheimer's. The University of Washington will apply explainable AI methods to human brain datasets to identify molecular drivers of brain aging, then manipulate these drivers in human induced pluripotent stem cell (iPSC) models to generate aging phenotypes in neurons and glia. This two-phase...