A translatable form of hypoxia therapy for impaired mitochondrial proteostasis
Ended Project Grant Awarded Last action
- Award ID
- R56AG088161
- Recipient
-
J.david Gladstone Institutes UEI KH6NJ6ND8737
- Awarding agency
-
National Institute on Aging
National Institutes of Health, Department of Health and Human Services
- Obligated
- $472,500
Award facts
- Assistance listing
- 93.866 Aging Research
- Completion date
- Place of performance
- California, USA
Award details come from USAspending.gov.
Description
- Abstract
- Our previous work demonstrated that hypoxic breathing, simulating high-altitude living, can prevent and reverse neurological damage in a mouse model of mitochondrial electron transport chain (etc) deficiency caused by mutations in a key complex 1 subunit. This research revealed that chronic hypoxia significantly extends lifespan and rescues biomarkers, behavior, and neuropathology. Building on these findings, a phase 1 clinical trial exposing healthy volunteers to controlled hypoxia was performed. To expand the understanding of hypoxia therapy's broader applicability, we are now testing the ability of low oxygen to rescue additional mitochondrial diseases caused by mutations in the mitochondrial proteostasis system. Furthermore, we propose investigating two potential mechanisms of hypoxia-mediated rescue: (1) activation of the hypoxia-inducible factor (HIF) transcriptional response to promote metabolic adaptations and (2) stabilization of iron-sulfur (FE-s) cluster-containing protein complexes affected by etc dysfunction. By elucidating these mechanisms, this research will provide critical insights into optimizing hypoxia-based therapies for mitochondrial diseases and inform treatment strategies for broader clinical applications.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Original award | $472,500 |
Quick answers
Who received award R56AG088161?
R56AG088161 was awarded to J.david Gladstone Institutes by National Institute on Aging (National Institutes of Health) on September 26, 2024.
How much is award R56AG088161 worth?
$472,500 has been obligated on R56AG088161.
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