Project Grant RF1AG086510

Award Date 6/15/24
Completion Date 5/31/27
Dollars Obligated $2.4M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Orangeburg, NY 10962, USA
Similar Awards
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $466,125 to Harvard Medical School to study the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neurons. The project aims to analyze the impacts of Alzheimer's-related mutations on RNA flow kinetics, including transcription, nuclear export, ribosome association, and degradation, within the soma and neuronal projections. Additionally,...
The Johns Hopkins University was awarded a $2,399,582 Project Grant from the National Institute on Aging (CFDA 93.866 Aging Research) to study extracellular vesicles derived from the brain as potential biomarkers for Alzheimer's disease. The 3-year grant, which begins on September 1, 2023, aims to identify specific cell surface markers and molecular signatures on brain-derived extracellular vesicles that could be used for early disease detection, monitoring, and understanding Alzheimer's...
This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $308,000.00 to investigate the impact of amyloid-beta 42 (Aβ42) on mitochondrial function in Alzheimer's disease. The overarching goal is to identify the mechanisms responsible for Aβ42's effects on the regulation of mitochondrial gene expression and mitochondrial dysfunction in a basic cell model. The central hypothesis is that Aβ42 interferes with mitochondrial liquid-liquid phase...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $246,750.00 to The Trustees of Columbia University in the City of New York to develop a pulse-labeling assay for tracking extracellular vesicle (EV) secretion and spreading in the murine brain. The goal is to use this assay to examine how the APOE4 genotype, the strongest genetic risk factor for Alzheimer's disease (AD), impacts EV dynamics in the dentate gyrus, one of the earliest brain...
The National Institute on Aging (NIA) awarded a $2,499,343 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Research Foundation for Mental Hygiene, Inc. (RFMH) to study the role of apolipoprotein E (APOE) genotype in modulating brain mitovesicle production, a key component of mitochondrial quality control. The project aims to elucidate the effects of APOE genotype on brain mitovesicle levels and content, both in humanized APOE mouse models and human brain tissue....
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $749,030 to The Trustees of Columbia University in the City of New York to conduct research on the mechanisms responsible for autophagy defects in neurons affected by Alzheimer's disease (AD). The research aims to investigate the connection between dysregulated calcium signaling and impaired autophagy in AD pathology, with the goal of validating novel therapeutic targets and lead...
This $4,950,026 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Icahn School of Medicine at Mount Sinai is investigating potential synergy between HIV infection and amyloid beta, a hallmark of Alzheimer's disease, in promoting memory impairment. Researchers will characterize enhanced HIV neuropathogenesis in familial and late-onset Alzheimer's disease mouse models...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $442,357 aims to elucidate the molecular mechanisms underlying the neurodegenerative reprogramming of microglia, the brain's primary immune cells, in Alzheimer's disease (AD). The key research objectives are to: 1) determine the mechanisms by which the Integrated Stress Response (ISR) pathway triggers chromatin remodeling in microglia, 2) test whether ISR exacerbates stressed microglia...
This $6,226,692 project grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to The Trustees of Columbia University in the City of New York. The grant will support research examining the role of neuronal hyperexcitability and proteostasis (regulation of protein life cycle) in the early progression of Alzheimer's disease (AD). The study aims to track electrophysiological changes and protein accumulation in the locus coeruleus...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,413,601.00 to the Research Foundation For Mental Hygiene, Inc. (RFMH) to investigate the role of extracellular vesicles, specifically mitovesicles, in Alzheimer's disease. The research aims to explore the cellular mechanisms involving mitovesicle generation, secretion, uptake, and intracellular fate in recipient brain cells under both physiological and pathological conditions. The study will analyze mitovesicles isolated from Alzheimer's disease mouse models and human brain tissue to identify changes that may contribute to the onset and progression of the disease, including mitochondrial dysfunction, oxidative stress, neuroinflammation, and synaptic impairment. The research also includes a sub-award to Columbia University to support this work. The findings have the potential to uncover new therapeutic directions for restoring mitochondrial integrity and mitigating the neurodegenerative consequences of Alzheimer's disease.

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