Project Grant R21AG084764

Award Date 8/1/24
Completion Date 7/31/26
Dollars Obligated $445K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Michigan, USA
Similar Awards
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a comprehensive investigation into the relationship between mitochondrial function and aging-related diseases. The $2,672,656 award to The Johns Hopkins University will leverage genetic variation data, metabolomics, and proteomics to identify novel biomarkers of mitochondrial function and assess their causal associations with all-cause mortality, cardiovascular disease, and frailty. The...
This Project Grant award, valued at $935,708 and provided by the National Institute on Aging (NIA) under CFDA 93.866 Aging Research, will support research to investigate the spatial and temporal heterogeneity of mitochondria and its relationship to physiological homeostasis throughout the lifespan. The primary awardee, Georgia TECH Research Corp, will utilize advanced in vivo chemical imaging techniques including broadband coherent anti-Stokes Raman scattering (BCARS) and two-photon fluorescence...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $388,067 to support an interdisciplinary investigation of functional asymmetry and topological restructuring within mitochondrial networks during cellular aging. The primary awardee is Northwestern University, which will partner with the University of California, San Diego on the project. The research aims to mechanistically investigate how mitochondrial positioning and dynamics contribute to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $399,766 to the University of Kansas Center for Research Inc. from January 1, 2025 to December 31, 2026. The project aims to understand the dynamics between mitochondrial and nuclear genome variation, and how this impacts mitochondrial dysfunction and associated diseases like neuromuscular disorders, cancers, and metabolic diseases. The research will leverage a novel animal model, the threespine...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $153,512.00 to the Regents of the University of Minnesota to conduct research on the relationship between lipid metabolism, mitochondrial stress, and cellular senescence. The key objectives are to: 1) use proteomics to characterize mitochondrial protein targets of carbonylation during obesity and aging, and 2) investigate the role of mitochondrial stress and signaling on adipose tissue...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research into the cell autonomous and cell non-autonomous roles of mitochondrial proline catabolism in health and longevity. The $126,042 award to the University of Southern California, effective February 1, 2025 through July 31, 2025, will employ innovative techniques including CRISPR/Cas9 genetic editing, single-cell RNA sequencing, and mitochondrial assessments to comprehensively characterize...
This Project Grant award of $308,000 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the mechanisms by which amyloid-beta 42 (Aβ42) interferes with mitochondrial liquid-liquid phase separation, causing morphological and functional mitochondrial defects in Alzheimer's disease. The two specific aims are: 1) to investigate the impact of Aβ42 on mitochondrial ribonucleoprotein granule dynamics, and 2) to use optogenetic control of Aβ42 and mitochondrial...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Washington provides $485,375 to investigate the mechanisms underlying reduced resilience and adaptability of aging skeletal muscle. The project aims to determine whether increased mitochondrial redox stress drives the impairment of redox stress response signaling and declining muscle function with age. The researchers will use skeletal muscle contraction as a model to examine the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $793,777 to the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco, CA, to study the impact of mitochondrial genome architecture on the accumulation of somatic mitochondrial DNA (mtDNA) mutations over an individual's lifetime. The research aims to understand how mtDNA compaction influences mutation rates and mitochondrial health, with potential...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Regents of the University of Michigan provides $445,144 in funding to examine the relationship between blood-based mitochondrial bioenergetic capacity in frozen samples, socioeconomic position, and physical functioning in older adults. The key objectives are to: 1) Test the reliability and validity of using the innovative Respirometry in Frozen Samples (RIFS) method to measure systemic markers of mitochondrial bioenergetic capacity in a population health study; 2) Explore the association between mitochondrial bioenergetic capacity and physical performance/function; and 3) Investigate the relationship between socioeconomic position and mitochondrial bioenergetic capacity.

Additionally, the University of California, San Diego will receive a $21,040 sub-award to oversee the analysis of mitochondrial function using the RIFS method on 234 samples from the Health and Retirement Study.

Generated 7/1/25, 4:11 AM