Project Grant R01AG086469
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- Federal Project Grant Award Summary The National Institute on Aging awarded a $673,012 Project Grant to the University of Massachusetts, beginning August 15, 2025, and extending through July 31, 2030, under the Aging Research program (CFDA 93.866). This research project will investigate the neuromechanical bases for increased energy cost of walking in older adults, a significant contributor to age-related mobility loss and a major public health concern. The research will examine how...
- Federal Project Grant Award Summary The University of Wisconsin-Madison received a $595,472 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded August 1, 2025, with a completion date of May 31, 2030. The grant supports scientific research directed toward understanding the physiological and molecular mechanisms by which calorie restriction (CR), prolonged fasting, and the mTORC1 protein kinase influence metabolism, healthspan, and longevity....
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
- Federal Grant Award Summary The National Institute on Aging awarded a $116,710 Project Grant to the University of Connecticut, Office Sponsored Programs, effective August 1, 2025 through April 30, 2030, under the Aging Research program (CFDA 93.866). This career development award supports research to establish sex-specific determinants of muscle quality in older adults, with particular focus on understanding how males and females experience different mechanisms of sarcopenia—the age-related loss...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $120,573 Project Grant to the University of Washington on September 1, 2025, supporting a Career Development Award for Dr. Matthew D. Campbell to conduct aging research (CFDA 93.866). Through May 31, 2030, Dr. Campbell will develop novel research capabilities and conduct scientific investigations into dysfunctional mitochondrial redox-sensitive signaling mechanisms in aged skeletal muscle. The research...
- Federal Grant Award Summary The University of Wisconsin System's Division at University of Wisconsin–Madison received a $1,271,506 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded July 1, 2025, with completion targeted for June 30, 2030. The Wisconsin Nathan Shock Center (WINSC) will conduct integrated research and training activities focused on the intersection of aging, metabolism, and translational science. The Center's primary...
- Federal Grant Award Summary Panorama Research Incorporated received a $354,000 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), with an award date of September 20, 2025, and completion date of September 19, 2026. The company will develop novel therapeutic formulations of Isthmin 1 (ISM1), an adipokine designed to address sarcopenia—age-related loss of skeletal muscle mass, strength, and quality. The research will generate...
- Federal Project Grant Award Summary New York University School of Medicine received a $466,125 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective January 15, 2026, with completion targeted for December 31, 2027. The award supports development of innovative magnetic resonance imaging (MRI) analysis tools and frameworks designed to identify microstructural and structural biomarkers of skeletal muscle health across the lifespan. The research...
- Federal Project Grant Award Summary The National Institute on Aging awarded the University of Virginia a $522,167 Project Grant, effective August 1, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). The award supports research investigating mechanisms of ribosomal DNA (rDNA) instability during aging, with the objective of understanding how genomic instability contributes to the aging process. The research focuses on characterizing the roles of the FOB1 protein and...
The National Institute on Aging awarded $698,690 to the University of Wisconsin-Madison under its Aging Research program (CFDA 93.866) effective February 1, 2026, through January 31, 2031. This Project Grant supports basic research investigating the molecular mechanisms underlying fiber type-specific skeletal muscle dysfunction in aging populations. The research project will deliver scientific findings and data products examining how aging affects slow versus fast muscle fibers differently, with specific focus on quantifying proteome changes associated with fiber-specific atrophy, determining cross-bridge contractile mechanisms, and identifying proteomic profiles that predict whole muscle dysfunction. The work addresses a significant health care problem—age-related loss of muscle power (dynapenia) and increased fatigability—which contributes to mobility limitations, fall risk, and reduced quality of life in older adults. The research will be conducted across three primary aims utilizing proteomics analysis and contractile function assessment in both male and female subjects, generating molecular and cellular data products to advance understanding of sarcopenia and age-related muscle dysfunction. As a five-year research initiative, this award represents the National Institute on Aging's investment in fundamental biomedical research directed toward understanding aging processes and developing evidence-based approaches for preventing and treating age-related conditions affecting older populations.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 1/28/26 | ||
| Not listed | $698.7k | 1/16/26 |