Project Grant P30AG092586

Award Date 7/1/25
Completion Date 6/30/30
Dollars Obligated $1.3M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will establish the Upstate NY Nathan Shock Center of Excellence in Basic Biology of Aging (Upstate NSC) to advance comparative biology research on aging. The $924,002 award, with a period of performance from July 1, 2025 to May 31, 2030, will fund four research resource cores: The Live Animal Core will maintain and share unique animal models of aging, including naked mole rats, Damaraland mole rats,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,270,502 to the Regents of the University of Minnesota to establish the Minnesota Nathan Shock Center of Excellence on Genome Integrity and Aging. The center will provide access to cores that can accurately measure DNA damage, DNA repair activity, and epigenetic changes associated with aging. It will also provide access to mouse and human cells and tissues, as well as mouse models with reduced...
This $101,925 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to investigate the role of the propionate metabolism pathway in the aging process. The 2-year project aims to: Continue studying the impact of methylmalonic acid (MMA), a metabolite in the propionate pathway, on cell senescence and aging-associated pulmonary fibrosis. Characterize a novel function of propionyl-CoA (P-CoA), another pathway...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support research by Tufts University School of Medicine to develop metabolomics clocks as a tool to explore the mechanisms of aging. The total funding amount is $592,507 and the award period runs from Sep 30, 2024 to Jun 30, 2029. The key objectives of the project are to: 1) develop sex- and tissue-specific metabolome clocks in the Drosophila model system that can...
This $270,000 Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) aims to provide comprehensive training in translational aging research and diverse career paths across academia, industry, and entrepreneurship. The award will support 15 doctoral or postdoctoral trainees over a 5-year period, enabling them to pursue research in aging while also gaining practical experience in various dimensions of translational research,...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
This federal Project Grant award of $2,496,057.49 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the role of hepatic glucagon receptor signaling in healthspan and aging. The research project at the University of Arizona will use genetic and pharmacological approaches to manipulate glucagon receptor signaling and study its impact on normal aging, obesity-accelerated aging, and calorie restriction-induced longevity extension. The project builds on prior...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of aging. The project aims to evaluate how a population of mouse T cells can be iteratively boosted and passaged among young mice for over 11 years, exceeding the normal mouse lifespan, while retaining functional competence and proliferative potential. The research will investigate factors such as...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
This Project Grant award of $395,796 from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research at Brown University to develop genetic, pharmacological, and dietary interventions that delay the onset and progression of age-related diseases. The key objectives are to: 1) Investigate the interconnectedness and hierarchical structure of the hallmarks of aging, such as loss of genomic integrity, activation of retrotransposons, and accumulation of lipid droplets; 2)...

This federal Project Grant award, identified as P30AG092586, was provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program. The award, totaling $1,271,506, will support the Wisconsin Nathan Shock Center (WINSC) to conduct research at the intersection of aging, metabolism, and translation.

The key objectives of the WINSC are to: 1) promote, coordinate, and enhance research in the basic biology of aging with a focus on aging, metabolism, and translation; and 2) advance cutting-edge research at the intersection of aging, metabolism, and translation by developing novel research capabilities and leveraging existing resources. To achieve these goals, the WINSC will establish three research cores: the Energetics of Longevity Core, the Discovery and Integration Core, and the Translation and Application Core. This comprehensive research program aims to advance the understanding of the biology of aging and devise novel hypotheses and interventions related to the intersection of aging and metabolism.

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