This three-year, $6.5 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research under the Aging Research program (CFDA 93.866). The grantee, the Regents of the University of Minnesota, will assess the acute and long-term impacts of SARS-CoV-2 infection on cognitive function and neuropathology in aging and Alzheimer's disease. Specifically, the University of Minnesota researchers will test hypotheses about how the...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will fund research to investigate whether SARS-CoV-2 proteins can accelerate the development of Alzheimer's disease pathology in fly and mouse models. The $419,375 award to the University of Florida will support a 2-year study to screen SARS-CoV-2 proteins and assess their effects on Alzheimer's-related amyloid-beta aggregation and neurodegeneration. The research aims to elucidate...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the impact of SARS-CoV-2 infection on the progression and severity of cerebral amyloid angiopathy (CAA) using a novel transgenic rat model. Specifically, the $630,000 award will fund two key research objectives over the project period from Sep 2024 to May 2026: Determine if the SARS-CoV-2 spike 1 protein accelerates the emergence and progression of CAA and associated pathologies in...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research into the role of SARS-CoV-2-induced cellular senescence in the development of Alzheimer's disease. The $369,823 award to the University of South Florida will fund a 5-year project to investigate how SARS-CoV-2 infection and the S1 subunit of the virus's spike...
This three-year, $4.68 million Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will support research into the collision of Alzheimer's disease and the COVID-19 pandemic in the United States. Funded under the Aging Research program, the grantee Case Western Reserve University will utilize a nationwide electronic health records database of over 80 million patients to examine COVID-19 risks and outcomes for those with Alzheimer's, including...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $663,376 to The Regents of the University of California, San Francisco to explore the molecular mechanisms underlying the heterogeneity of Alzheimer's disease and related dementias. The project aims to identify key genes that mediate the selective vulnerability of brain regions to distinct pathological protein conformers, such as tau and alpha-synuclein, using a novel computational modeling...
The National Institute on Aging (NIA) awarded a 3-year, $2,561,480 Project Grant (CFDA 93.866) to Brigham & Women's Hospital to study the post-acute sequelae of SARS-CoV-2 infection (PASC) and subsequent disease progression in individuals with mild cognitive impairment (MCI) or Alzheimer's disease (AD) and related dementias (ADRD). The project aims to: 1) understand the epidemiology of PASC in cognitively impaired individuals; 2) examine the impacts of COVID-19 and PASC on disease...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $639,740.00 to investigate the role of the CD38 enzyme in the development of chronic lung conditions following viral infections like COVID-19. The research aims to explore how targeting CD38 on CD8 tissue resident memory (TRM) cells could mitigate age-associated lung fibrosis after viral pneumonia. The award, effective December 15, 2024 through November 30, 2029, will support the lead researcher...
The National Institute on Aging (NIA) awarded a $1,281,004 Project Grant under the Aging Research federal grant program (CFDA 93.866) to The University of North Carolina at Charlotte to investigate the interactions between viral infection, tau pathology, and neuroinflammation. The 3-year research project aims to determine whether viral infection increases tau pathology, assess the impact of tau aggregation on viral replication, and examine the effect of tau pathology on the neuroinflammatory...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...