The National Institute on Aging (NIA) awarded a $639,740 Project Grant under the Aging Research program (CFDA 93.866) to Rector & Visitors of the University of Virginia (UVA) to investigate the role of the CD38 enzyme and CD8 tissue-resident memory T cells in the development of chronic lung fibrosis following viral pneumonia, including COVID-19. The research aims to provide mechanistic insights into post-viral lung sequelae and explore potential targeted immunotherapies to preserve lung function, particularly in the elderly. As a sub-awardee, Mayo Clinic Jacksonville will provide expertise on CD38 biology and NAD+ metabolism to support the project.
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