This three-year, $4.68 million Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will support research into the collision of Alzheimer's disease and the COVID-19 pandemic in the United States. Funded under the Aging Research program, the grantee Case Western Reserve University will utilize a nationwide electronic health records database of over 80 million patients to examine COVID-19 risks and outcomes for those with Alzheimer's, including...
This three-year, $6.5 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research under the Aging Research program (CFDA 93.866). The grantee, the Regents of the University of Minnesota, will assess the acute and long-term impacts of SARS-CoV-2 infection on cognitive function and neuropathology in aging and Alzheimer's disease. Specifically, the University of Minnesota researchers will test hypotheses about how the...
This $1,120,805 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), will support research to investigate how prior SARS-CoV-2 infection may increase the risk of vascular contributions to cognitive impairment and dementia (VCID). The research aims to: Determine how prior SARS-CoV-2 infection influences blood-brain barrier...
The National Institutes of Health's Office of the Director awarded a $8,661,331 project grant under the Lung Diseases Research program (CFDA 93.838) to the Massachusetts General Hospital on June 10, 2021 for the development of interactive data portals and analytic tools to support Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) cohorts. Key products and services delivered through Massachusetts General Hospital and several sub-awardees include an interactive data portal called the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,858,368.00 to Brigham & Women's Hospital Inc. to support research on the role of the SORL1-retromer biology in the pathogenesis of Alzheimer's disease. The award has an initial term from September 30, 2024 to August 31, 2027. Brigham & Women's Hospital Inc. is a prominent academic medical center and research institution in Boston, Massachusetts, affiliated with Harvard Medical...
This $917,701 federal Project Grant award under the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 5-year study conducted by Brigham & Women's Hospital to implement and evaluate an Acute Hospital Care at Home (AHCAH) pathway specifically for people living with dementia. The study aims to: 1) Evaluate the effect of a pre-enrollment AHCAH pathway on quality of life over 12 months for persons with moderate to severe dementia (Aim 1); and 2) Evaluate the...
The National Institute of Mental Health (NIMH) awarded a Project Grant (CFDA 93.242) in the amount of $797,157 to Yale University to conduct research on understanding circuit dysfunction in post-acute sequelae of SARS-CoV-2 infection (PASC) with neuropsychiatric manifestations. The project aims to leverage Yale's expertise in neuroscience and neuroimaging to identify brain circuit-level changes and potential compensatory mechanisms associated with cognitive deficits and mood alterations observed...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $630,000 to the University of Rhode Island to investigate the impact of SARS-CoV-2 infection on a novel transgenic rat model of cerebral amyloid angiopathy (CAA). The two-year project, running from September 2024 to May 2026, aims to determine if the SARS-CoV-2 spike protein accelerates the emergence and progression of CAA pathology, as well as exacerbates associated vasculopathies in...
This $834,094 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to advance research on post-stroke cognitive impairment and dementia (PSCID). The funding will support a multi-year effort leveraging a national stroke registry and Medicare data to determine the incidence and prevalence of PSCID, identify associated risk factors, and explore potential pharmacological prevention strategies. Key aspects of the research include a patient-centered approach,...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to understand the mechanisms by which SARS-CoV-2 infection can lead to long-lasting neurological impacts known as post-acute sequelae of COVID-19 (NEUROPASC). The $801,329 grant, with a period of performance from December 1, 2024 to November 30, 2029, will be...