This three-year, $4.68 million Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will support research into the collision of Alzheimer's disease and the COVID-19 pandemic in the United States. Funded under the Aging Research program, the grantee Case Western Reserve University will utilize a nationwide electronic health records database of over 80 million patients to examine COVID-19 risks and outcomes for those with Alzheimer's, including potential disparities. They will also study new onset of Alzheimer's in COVID-19 survivors and characterize long-term neurological post-acute sequelae of COVID-19 in survivors with Alzheimer's. Finally, the university will investigate therapeutic effects of tumor necrosis factor blockers on mortality and long-haul symptoms for COVID-19 survivors with Alzheimer's. By establishing methods for real-time analysis of health records across tens of millions of aging Americans, this research aims to better prepare for future pandemics and their interaction with existing conditions like Alzheimer's disease.
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