Project Grant R21AG089374

Award Date 9/15/24
Completion Date 5/31/26
Dollars Obligated $630K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Kingston, RI 02881, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,659,973 to the University of South Florida to investigate the molecular mechanisms underlying neurological sequelae, known as "Neuro-COVID", experienced by individuals following SARS-CoV-2 (COVID-19) infection. The research aims to characterize age-dependent COVID-19-induced tau pathology and cognitive decline in mouse models, identify key molecular targets such as FKBP51 and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate whether SARS-CoV-2 proteins can accelerate the development of Alzheimer's disease pathology in fly and mouse models. The $419,375 award to the University of Florida will fund a 2-year study (1/1/2025 - 12/31/2026) to screen SARS-CoV-2 proteins for their potential to induce neurodegeneration and exacerbate amyloid-beta aggregation, key hallmarks of Alzheimer's disease....
This three-year, $6.5 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research under the Aging Research program (CFDA 93.866). The grantee, the Regents of the University of Minnesota, will assess the acute and long-term impacts of SARS-CoV-2 infection on cognitive function and neuropathology in aging and Alzheimer's disease. Specifically, the University of Minnesota researchers will test hypotheses about how the...
This federal Project Grant award of $794,341.00, provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program, is funding research to investigate the mechanistic roles of cellular senescence and blood-brain barrier dysfunction in mediating pathogen-induced Alzheimer's disease (AD) progression. The key goals are to leverage experimental mouse models, molecular characterization of endogenous retrovirus RNA sensing, and human iPSC models to elucidate how...
This federal Project Grant award of $369,823 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund research at the University of South Florida to investigate the role of SARS-CoV-2-induced cellular senescence in the development of Alzheimer's disease. The key objectives are to explore how SARS-CoV-2 infection promotes cellular senescence in the brain, particularly...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at Virginia Commonwealth University (VCU) to investigate the effect of the trans-synaptic spread of pathogenic tau protein in the hippocampus and its impact on vulnerable neuron subtypes in Alzheimer's disease (AD). The $408,638 award, effective from August 1, 2024 to July 31, 2026, will involve the use of adeno-associated viral vector transfection, immunofluorescence, and...
This $200,323 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research by the University of South Florida to investigate the aggregation of amyloid-beta (Aβ) peptides during metabolic stress and spreading depolarization events in the brain. The project will utilize multiscale modeling, high-resolution microscopy, antibody staining, and paralysis phenotype testing in C. elegans to determine how physiochemical changes...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $10,847,672 to the J. David Gladstone Institutes to investigate the vascular-immune mechanisms underlying cerebral amyloid angiopathy (CAA) and Alzheimer's disease pathology. The key products and services to be delivered under this award include: Profiling over 200 human postmortem brain samples from the ROSMAP study using advanced single-cell genomics and spatial genomics approaches to...
The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $460,625 Project Grant to the University of Massachusetts Medical School (UMass Medical) on May 15, 2025. The grant will fund a 2-year research project titled "Platelet-MLKL Role in S100 Release with Age and Infection" that aims to investigate the mechanisms by which advanced age and respiratory viral infections, such as influenza, SARS-CoV-2, and RSV, contribute to thrombotic outcomes....
The National Institute on Aging (NIA) awarded a 3-year, $2,561,480 Project Grant (CFDA 93.866) to Brigham & Women's Hospital to study the post-acute sequelae of SARS-CoV-2 infection (PASC) and subsequent disease progression in individuals with mild cognitive impairment (MCI) or Alzheimer's disease (AD) and related dementias (ADRD). The project aims to: 1) understand the epidemiology of PASC in cognitively impaired individuals; 2) examine the impacts of COVID-19 and PASC on disease...

This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $630,000 to the University of Rhode Island to investigate the impact of SARS-CoV-2 infection on a novel transgenic rat model of cerebral amyloid angiopathy (CAA). The project aims to determine if the SARS-CoV-2 spike 1 protein accelerates the emergence and progression of CAA, as well as exacerbates CAA-associated vasculopathies, in the RTG-D rat model. The research will combine quantitative pathological measures and transcriptomic approaches to identify key activation pathways shared between CAA and SARS-CoV-2 infection. The award period runs from September 15, 2024 to May 31, 2026.

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