The National Institute on Aging (NIA) awarded a $419,375 Project Grant (CFDA 93.866 - Aging Research) to the University of Florida to investigate whether SARS-CoV-2 proteins can accelerate the development of Alzheimer's disease pathology in fly and mouse models. The study will screen all 29 SARS-CoV-2 proteins to identify any that may induce aggressive neurodegeneration and exacerbate amyloid-beta aggregation, a hallmark of Alzheimer's disease. The researchers will conduct age-dependent genetic,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate the role of pathogen-induced cellular senescence and blood-brain barrier dysfunction in the development and progression of Alzheimer's disease. The $794,341 award, effective from January 1, 2025 through December 31, 2029, will be conducted by the University of Illinois in Chicago. The research aims to leverage experimental mouse models, molecular characterization of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the molecular mechanisms underlying COVID-19-induced neurological sequelae and tauopathy (abnormal tau protein accumulation). With $3,659,973 in total funding over a period of nearly 5 years (9/15/2024 - 5/31/2029), the University of South Florida will: Assess how aging exacerbates inflammation leading to tauopathy and cognitive decline in a mouse model of COVID-19...
This three-year, $6.5 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research under the Aging Research program (CFDA 93.866). The grantee, the Regents of the University of Minnesota, will assess the acute and long-term impacts of SARS-CoV-2 infection on cognitive function and neuropathology in aging and Alzheimer's disease. Specifically, the University of Minnesota researchers will test hypotheses about how the...
This three-year, $4.68 million Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will support research into the collision of Alzheimer's disease and the COVID-19 pandemic in the United States. Funded under the Aging Research program, the grantee Case Western Reserve University will utilize a nationwide electronic health records database of over 80 million patients to examine COVID-19 risks and outcomes for those with Alzheimer's, including...
This $1,120,805 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), will support research to investigate how prior SARS-CoV-2 infection may increase the risk of vascular contributions to cognitive impairment and dementia (VCID). The research aims to: Determine how prior SARS-CoV-2 infection influences blood-brain barrier...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
This $1,425,000 project grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into neuronal senescence and inflammation in Alzheimer's disease. The Salk Institute for Biological Studies will study the interaction between cellular senescence and inflammation in induced neurons derived from Alzheimer's patients and healthy aged controls. Researchers will examine differences in gene expression and epigenetic...
This $200,323 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research by the University of South Florida to investigate the aggregation of amyloid-beta (Aβ) peptides during metabolic stress and spreading depolarization events in the brain. The project will utilize multiscale modeling, high-resolution microscopy, antibody staining, and paralysis phenotype testing in C. elegans to determine how physiochemical changes...
The National Institute on Aging (NIA) awarded a 3-year, $2,561,480 Project Grant (CFDA 93.866) to Brigham & Women's Hospital to study the post-acute sequelae of SARS-CoV-2 infection (PASC) and subsequent disease progression in individuals with mild cognitive impairment (MCI) or Alzheimer's disease (AD) and related dementias (ADRD). The project aims to: 1) understand the epidemiology of PASC in cognitively impaired individuals; 2) examine the impacts of COVID-19 and PASC on disease...