This three-year, $6.5 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research under the Aging Research program (CFDA 93.866). The grantee, the Regents of the University of Minnesota, will assess the acute and long-term impacts of SARS-CoV-2 infection on cognitive function and neuropathology in aging and Alzheimer's disease.
Specifically, the University of Minnesota researchers will test hypotheses about how the interactions of SARS-CoV-2 with age, apolipoprotein E genotype, and Alzheimer's-type neuropathology modulate neuroinflammation and affect brain function outcomes from SARS-CoV-2 infection. They will study these factors using multiple mouse models and a combination of virology, immunology, and neurobehavioral approaches. This includes innovative single cell/nucleus transcriptomics, spatial genomics, and 3D brain clearing and imaging technologies. The research aims to define short- and long-term impacts of SARS-CoV-2 infection on cognitive aging processes and define underlying cellular and molecular mechanisms, with the goal of informing future interventions.
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