This $2,356,117 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research to improve the perioperative management of patients with Alzheimer's disease and related dementias. The primary objectives are to: (1) identify the extent to which surgical patients with these conditions are at increased risk for adverse postoperative outcomes, and (2) estimate the association between various perioperative interventions and the incidence...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop effective, scalable tools and interventions to reduce postoperative mortality, delirium, cognitive decline, and other adverse outcomes in vulnerable elderly surgical patients. The 5-year, $801,268 award to the University of Pittsburgh will fund research to create reliable preoperative risk prediction models and enable proactive multimodal perioperative interventions, including...
This Project Grant from the National Institutes of Health National Institute on Aging provides $4,489,362 to Duke University from September 15, 2022 through August 31, 2025 under the Aging Research program (CFDA 93.866). The grant will fund research to identify mechanisms of blood-brain barrier dysfunction in delirium superimposed on dementia after surgery. Specifically, the researchers will characterize how the postoperative systemic environment impacts the blood-brain barrier using...
Duke University has been awarded a $4,537,430 Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, to support research under the Aging Research program (CFDA 93.866). The grant will fund a study from September 2022 to August 2025 to examine the role of cellular senescence on postoperative neuroinflammation. Specifically, the researchers will use a mouse model of orthopedic fracture to determine how senescent cell burden exacerbates systemic...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $805,295 to The Leland Stanford Junior University to conduct a study examining cerebrospinal fluid (CSF) and blood biomarkers to gain insight into postoperative delirium and neurocognitive dysfunction. The 5-year study will enroll 180 patients undergoing aortic surgery, collecting serial CSF and blood samples to determine if biomarkers related to blood-brain barrier injury, inflammation,...
This Project Grant award from the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, provides $715,801 to Duke University to investigate the causal role of blood-brain barrier dysfunction and neuroinflammation in exacerbating postoperative delirium and subsequent onset of Alzheimer's disease and related dementias in aging and hypertension. The overarching goal is to elucidate how hypertension primes the neurovascular unit and worsens delirium-like behavior after orthopedic...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $124,050.00 to The Regents of the University of California, San Francisco (UCSF) to investigate the molecular mechanisms underlying synapse loss in Alzheimer's disease (AD). The key objectives are to: 1) Determine how IL-6 and IL-11 signaling pathways affect synaptic phosphatidylserine (PS) exposure, glial synaptic engulfment, and in vivo synaptic function in AD models; and 2) Identify other...
This Project Grant award of $372,690 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to discover the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The project will develop new statistical methods to uncover how amyloid-beta, tau accumulation, and cognition are causally related in different AD subpopulations. The goal is to reveal optimal treatment windows and target groups for therapies that reduce amyloid-beta or...
This $1,230,000 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support the development and deployment of closed-loop digital interventions through a remote clinical trials platform. The overarching goal is to leverage technology to facilitate memory and cognitive function and prevent or delay age-related cognitive decline, particularly in older adults at risk of Alzheimer's disease and related dementias. The...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $299,893 to Pascall Systems, Inc. to develop a novel system that combines pre-operative cognitive assessment with Pascall's FDA-cleared wireless EEG technology for intraoperative monitoring. The goal is to enable personalized anesthesia care and effective monitoring of postoperative neurocognitive disorders (PNDs) in elderly surgical patients. The key products and services to be delivered...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), is supporting research to investigate the role of interleukin-6 (IL-6) trans-signaling in the development of postoperative cognitive decline in aging and Alzheimer's disease. The total award amount is $3,284,161 over the project period from September 15, 2024 to May 31, 2029. The research will be conducted by The Regents of the University of California, San Francisco to address several key questions regarding the mechanisms and potential therapeutic interventions for perioperative neurocognitive disorders in high-risk surgical populations. The findings from this project are expected to inform the development of critically needed therapies for safely preventing and reversing postoperative cognitive impairments in older adults and those with neurodegenerative disorders.